Table 3. Associations of the APOE ε2 and ε4 alleles with FEV1, FVC and FEV1/FVC in the sub-group of 3,832 genotyped LLFS participants without lung disease.
| Trait | Effect allele |
Men & Women | Men | Women | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | P-value | Beta | SE | P-value | Beta | SE | P-value | ||
| FEV1 | ε2 | -5.44 | 22.92 | .812 | 12.01 | 37.73 | .750 | -23.90 | 26.13 | .360 |
| ε4 | 10.21 | 22.15 | .645 | 44.26 | 38.25 | .247 | 0.11 | 24.45 | .996 | |
| FVC | ε2 | -29.89 | 29.36 | .309 | -48.00 | 48.70 | .324 | -21.31 | 33.67 | .527 |
| ε4 | 33.57 | 27.47 | .222 | 70.34 | 46.89 | .134 | 31.26 | 31.42 | .320 | |
| FEV1/FVC | ε2 | 0.16 | 0.32 | .605 | 0.45 | 0.48 | .349 | -0.03 | 0.42 | .936 |
| ε4 | -0.72 | 0.30 | .016* | -0.46 | 0.46 | .312 | -1.04 | 0.39 | .008* | |
The models were fitted with adjustments by age, sex, family groups, and field center.
Controls subjects without lung disease are defined in the Methods section.
The ε3/ε3 genotype was considered as the reference.
* denotes significant result (p-value < 0.05).