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Let-7f-5p is involved in M1 polarization of macrophage induced by PMMA. RAW264.7 cells were divided into four groups: control, PMMA, PMMA+ NC (negative control of let-7f-5p inhibitor) and PMMA+ let-7f-5p inhibitor. (a) The concentration of TNF-α and IL-10 in RAW264.7 cells was detected by ELISA. *P < 0.05 vs. control. &P < 0.05 vs. PMMA+ NC. (b) The expression of iNOS and Arg1 in RAW264.7 cells was quantified by qRT-PCR. *P < 0.05 vs. control. &P < 0.05 vs. PMMA+ NC.
