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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Mol Neurobiol. 2017 Nov 11;55(7):5976–5992. doi: 10.1007/s12035-017-0816-8

Fig. 4. HIV-1 and TLR3 ligands upregulate IL6 expression in HBMEC.

Fig. 4

Exposure of HBMEC to PIC [0.5 ng/ml to 5 µg/ml (a) or 10 to 75 µg/ml (b)] induced IL6 expression and secretion. Experiments in panels a and b were performed using endothelial cells from two different human donors. Experiments using HBMEC from a third donor (c) showed that exposure of HBMEC to PIC (25 to 50 µg/ml) or HIV-1ADA (MOI: 0.001) induced IL6 expression and secretion; and the TLR3/dsRNA complex inhibitor (TLR3.CI) blocked both PIC- and HIV-1-induced IL6 expression (c). ***P<0.001.