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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Mol Neurobiol. 2017 Nov 11;55(7):5976–5992. doi: 10.1007/s12035-017-0816-8

Fig. 6. The TLR3/dsRNA complex inhibitor blocked both TLR3 ligands- and HIV-1-induced transcriptional upregulation of IL6 and transcription factors associated with the TAK1 and JNK pathways.

Fig. 6

Quantitative real-time PCR showed that exposure of HBMEC to PIC (50 µg/ml) and HIV-1ADA (MOI: 0.001) for 24 hours induce transcriptional upregulation of IL6 (a), JUN (b), RELB (c), CEBPA (d), CEBPG (e), and STAT1 (f). The inhibitor of TLR3/dsRNA complex (TLR3.CI) blocked both PIC- and HIV-1-induced upregulation of IL6 (a), JUN (b), RELB (c), CEBPA (d), CEBPG (e), and STAT1 (f). *P<0.05, **P<0.01, ***P<0.001. These are representative data from three independent experiments using HBMEC from three different human donors.