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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Mol Neurobiol. 2017 Nov 11;55(7):5976–5992. doi: 10.1007/s12035-017-0816-8

Fig. 7. HIV-1 and TLR3 ligands induced the phosphorylation of c-Jun and JNK in HBMEC.

Fig. 7

(a): Exposure of primary HBMEC to the TLR3 ligand PIC (50 µg/ml) induced the phosphorylation of c-Jun at Ser63, with maximal phosphorylation at 2 hours; increased c-Jun, and increased the phosphorylation of SAPK/JNK at Thr183/Tyr185. (b): Exposure of primary HBMEC to HIV-1ADA (MOI: 0.001) induced the phosphorylation of c-Jun at Ser63 and SAPK/JNK at Thr183/Tyr185. (c): The inhibitor of TLR3/dsRNA complex (TLR3.CI) blocked PIC- and HIV-1-induced phosphorylation of c-Jun and SAPK/JNK. These are representative data from two independent experiments using HBMEC from two different human donors.