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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: Mol Neurobiol. 2017 Nov 11;55(7):5976–5992. doi: 10.1007/s12035-017-0816-8

Fig. 8. The JNK and TAK1/MKK7 pathways mediate TLR3 ligands- and HIV-1- induced IL6 expression HBMEC.

Fig. 8

(a) The JNK inhibitor 420119, the ATP-competitive JNK inhibitor 420129, and the TAK1/MKK7 inhibitor 5ZO blocked PIC induced IL6 expression and secretion. (b): PIC induced IL6 expression was reduced by the inhibitor of AP-1 transcriptional activity SR11302, whereas the inhibitor of NFκB transcriptional activation 481406, the IRAK1/4 inhibitor, and the inhibitor of c-Jun/JNK complex 420130 had minimal to no effect. (c): The ATP-competitive JNK inhibitor 420129, the IRAK1/4 inhibitor, and the TAK1/MKK7 inhibitor 5ZO blocked HIV-1-induced IL6 expression and secretion; whereas the JNK inhibitor 420119, the inhibitor of c-Jun/JNK complex 420130, the inhibitor of NFκB transcriptional activation 481406, and the inhibitor of AP-1 transcriptional activity SR11302, had minimal to no effect. *P<0.05, **P<0.01, ***P<0.001.