Table 1.
Clinical history of brain tissues donors
| HIV-1 Status |
ID | Gender/ Age (y) |
PMI (h) |
Neurocognition/ Neuropathology |
Other autopsy diagnosis |
|---|---|---|---|---|---|
| Neg | N1 | M/35 | 8.5 | Normal/None | Mild Alzheimer gliosis |
| Neg | N2 | N/A | N/A | Normal/None | N/A |
| Neg | N3 | F/38 | 5.75 | Normal/Not significant | Mild gliosis, lung and bile duct carcinoma |
| Neg | N4 | M/32 | 4.25 | Normal/Not significant | Cystic fibrosis, and multiorgan failure |
| Neg | N5 | F/46 | 4 | Normal/Not significant | Mild fibrosis, mild patchy gliosis |
| Neg | N6 | F/49 | 4.5 | Normal/Not significant | Hepatic cirrhosis, liver failure |
| Neg | N7 | M/52 | 5.25 | Normal/None | Hypertension, renal failure |
| Neg | N8 | M/72 | 3 | Normal/None | Hypertension, COPD |
| Neg | N9 | M/64 | 3.3 | Normal/None | Hepatic carcinoma |
| Neg | N10 | M/56 | 3 | Normal/Not significant | Lung adenocarcinoma, mild nonspecific cortical atrophy |
| Neg | N11 | M/67 | 3.5 | Normal/None | COPD, TB |
| Neg | N12 | M/61 | 5.75 | Normal/Not significant | Cardiomyopathy, mild gliosis |
| Pos | P1 | ?/46 | 2.75 | Normal/None | N/A |
| Pos | P2 | ?/27 | 8 | Normal/None | N/A |
| Pos | P3 | ?/37 | 5 | Normal/None | N/A |
| Pos | P4 | M/39 | 11 | Normal/None | Minimal non-diagnostic abnormalities |
| Pos | P5 | M/35 | 6.5 | Normal/None | Non-Hodgkins lymphoma, AIDS |
| Pos | P6 | M/54 | 6.5 | Normal/None | AIDS |
| Pos | P7 | M/48 | 15 | Normal/None | Liver disease |
| Pos | P8 | M/52 | 8 | Normal/None | AIDS |
| Pos | P9 | M/38 | 14 | Normal | Pneumonia, hemophilia A, AIDS |
| Pos | HAND1/D1 | M/30 | 6 | HAND/HIVE | Minimal terminal anoxia |
| Pos | HAND2/D2 | ?/50 | 21 | HAND/HIVE | N/A |
| Pos | HAND3/D3 | ?/39 | 12 | HAND/HIVE | N/A |
| Pos | HAND4/D4 | ?/40 | 12 | HAND/HIVE | N/A |
| Pos | HAND5/D5 | M/47 | 11 | HAND/HIVE | Encephalopathy, microglial nodule encephalitis, meningoencephalitis with microvascular damage |
| Pos | HAND6/D6 | M/40 | 5 | HAND/HIVE | Non-Hodgkin’s lymphoma, AIDS, lymphocytic meningitis |
| Pos | HAND7/D7 | M/44 | 4 | HAND/HIVE | Microglial nodules, astrocytosis, widespread gliosis, AIDS |
| Pos | HAND8/D8 | M/52 | 5 | HAND/HIVE | Atherosclerosis |
| Pos | HAND9/D9 | M/34 | 11.5 | HAND/HIVE | AIDS |
| Pos | HAND10/D10 | M/38 | 7 | HAND/HIVE | HIV encephalopathy / Leukoencephalopathy, AIDS |
Neg indicates HIV seronegative; Pos, HIV seropositive; HAND, HIV-associated neurocognitive disorders; HIVE, HIV encephalitis; y, years; M, male; F, female; ? or N/A, not available; and PMI, postmortem interval; AIDS, acquired immunodeficiency syndrome; COPD, chronic obstructive pulmonary disease; TB, tuberculosis.