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. 2018 Nov 9;4(11):eaau6972. doi: 10.1126/sciadv.aau6972

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Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 3 — (A) Results of MTT assay in the cytotoxicity tests of HDF cells interfaced with the Si NN-patch (green) and control Si NNs on a Si wafer (red) and a bare Si wafer (yellow). Error bar represents the SD of three replicates. (B) Results of LDH assay in the invasiveness tests of HDF cells for 2 days. Triton X-100 is used as a positive control (blue). Error bar represents the SD of three replicates. (C) SEM images of MCF7 cells on a representative Si NN-patch at 24 hours after nanoinjection. Scale bar, 10 μm. Arrows highlight the deformed Si NNs by cell deformations. (D) Time-lapsed live differential interference contrast (DIC) images of HDF cells that interacted with Si NNs at the bottom. Scale bar, 10 μm.