Table 2.

Determinants of high sensitivity troponin I levels at day 3 after intubation.

	Ratio of geometric means (95% confidence interval)	P-value
High-sensitivity troponin, day 0†	46.44 (37.01 – 58.28)	<0.001
Age	1.46 (1.16 – 1.84)	0.001
Temperature, day 0	0.63 (0.50 – 0.78)	<0.001
Heart rate, day 0†	1.20 (0.95 – 1.52)	0.009
FiO2, day 0	1.26 (0.99 – 1.60)	0.06
Creatinine, day 0†	4.06 (1.72 – 9.59)	<0.001
Vasopressoruse, day 3 (yes vs. no)	1.33 (1.06 – 1.69)	0.016
pH, day 3	0.48 (0.39 – 0.60)	<0.01

Values in the Table are ratios of geometric means calculated from linear regression models with log-high sensitivity troponin I levels at day 3 as outcome. For categorical variables, the ratios are compared with respect to the reference category. For continuous variables, the ratios compare the 90^th to the 10^th percentiles of the predict or variable in the overall study sample. The 90^th and 10^th percentiles were, for log high-sensitivity troponin at day 0, 6.71 and 1.06 log(ng/L); for age, 73 and 30 years; for temperature at day 0, 38.8 and 36.3 °C; for heart rate at day 0, 127 and 74 beats per minute; for FiO₂ at day 0, 1.0 and 0.4; for creatinine at day 0, 2.7 and 0.5 mg/dL; and for pH at day 3, 7.48 and 7.28.

Ratios of geometric means were adjusted for other variables in the Table. Variables were included in the multivariable model if P <0.10 in the univariable model, and after a stepwise selection method with retention if P<0.10 in the multivariable model (see Methods for details). Values in the Table were calculated using multiple imputation to take missing data into account (see Supplemental Table 1 for description of data available for each variable).

^†Modeled as restricted cubic splines to accommodate non-linear associations (see Methods for details).