Table 3.
Hazard ratios for 60-day mortality by quintile of % change in high sensitivity troponin I levels between the day of intubation (day 0) and day 3.
| Quintile of % change in hs-troponin between day 0 and day 3 (range) |
||||||
|---|---|---|---|---|---|---|
| First (−98.5 to −81.8%) | Second (−81.8 to −67.6%) | Third (−67.6 to −40.7%) | Fourth (−40.7 to 32.1%) | Fifth (>32.1%) | P trend | |
| Number of participants | 181 | 182 | 181 | 182 | 182 | |
| Mean hs-troponin at day 0, ng/L | 1,843.2 | 1,947.6 | 362.8 | 569.2 | 173.0 | |
| Mean hs-troponin at day 3, ng/L | 178.7 | 470.2 | 158.5 | 403.2 | 721.7 | |
| Mean change in hs-troponin (%) | −89.1 | −75.4 | −56.7 | −10.3 | 1,442.2 | |
| Number of deaths (%) | 27 (14.9) | 34 (18.7) | 49 (27.1) | 47 (25.8) | 68 (37.4) | |
| Model 1 | ||||||
| Hazard ratio (95% confidence interval) | 1.00 (reference) | 1.40 (0.84 – 2.35) | 2.14 (1.32 – 3.49) | 2.35 (1.41 – 3.91) | 3.88 (2.39 – 6.32) | <0.001 |
| Model 2 | ||||||
| Hazard ratio (95% confidence interval) | 1.00 (reference) | 1.42 (0.80 – 2.49) | 1.99 (1.16 – 3.41) | 2.11 (1.20 – 3.70) | 3.22 (1.86 – 5.59) | <0.001 |
| Model 3 | ||||||
| Hazard ratio (95% confidence interval) | 1.00 (reference) | 1.28 (0.72 – 2.27) | 1.67 (0.96 – 2.89) | 1.63 (0.92 – 2.90) | 2.27 (1.29 – 3.99) | 0.002 |
Values in the Table were calculated using multiple imputation to take missing data into account (see Supplemental Table 1 for description of data available for each variable).
Model 1: Adjusted for age, sex, randomized trial assignment, and hs-troponin levels at day 0 (quintiles).
Model 2: Further adjusted for SOFA score at day 0.
Model 3: Further adjusted for use of vasopressors at day 0 and day 3, heart rate at day 0 and day 3, and total fluid balance between day 0 and day 3 (continuous).