Table 2a.
Bivariate and Adjusted Associations of Candidate Phenotypes with ADH1B Polymorphisms by Population Group
| Bivariate Association | Ordered Logit Model | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Pearson’s χ2 | Test of Trend | ||||||||
| χ2 | p-value | χ2 | p-value | LR test | df | Pseudo R2 | p-value | ||
| Association of rs2066702 with Candidate Phenotypes Among African Americans | |||||||||
| Age-adjusted mean AUDIT-Ca | 166 | 5.13 e-28 | 109 | 1.11 e-16 | 149.52 | 7 | 0.0143 | 5.12 e-29 | |
| AUDIT-C trajectoriesb | 112 | 7.60 e-22 | 68 | 9.06 e-13 | 102.40 | 3 | 0.0138 | 4.73 e-22 | |
| AUD codesc | 104 | 2.13 e-23 | 100 | 2.09 e-22 | 108.61 | 1 | 0.0138 | 1.98 e-25 | |
| Age-adjusted mean AUDIT-C + AUDIT-C trajectoriesd | n/a | -- | n/a | -- | 150.09 | 10 | 0.0143 | 3.56 e-27 | |
| Age-adjusted mean AUDIT-C + AUD codesd | n/a | -- | n/a | -- | 198.97 | 8 | 0.0149 | 1.05 e-38 | |
| Association of rs1229984 with Candidate Phenotypes Among European Americans | |||||||||
| Age-adjusted mean AUDIT-Ca | 268 | 5.40 e-49 | 159 | 2.13 e-36 | 244.37 | 7 | 0.0557 | 4.38 e-49 | |
| AUDIT-C trajectoriesb | 205 | 1.53 e-41 | 68 | 1.62 e-16 | 197.56 | 3 | 0.0548 | 1.42 e-42 | |
| AUD codesc | 183 | 1.85 e-40 | 178 | 1.58 e-40 | 158.79 | 1 | 0.0541 | 2.08 e-36 | |
| Age-adjusted mean AUDIT-C + AUDIT-C trajectoriesd | n/a | -- | n/a | -- | 250.45 | 10 | 0.0558 | 4.36 e-48 | |
| Age-adjusted mean AUDIT-C + AUD codesd | n/a | -- | n/a | -- | 321.91 | 8 | 0.0572 | 8.88 e-65 | |
AUDIT-C=Alcohol Use Disorders Identification Test-Consumption; AUD=alcohol use disorder; LR=likelihood ratio; df=degrees of freedom.
a
8-level ordinal measure
b
4-group trajectory
c
Based on ICD-9/10 codes
d
The combination of AUDIT-C measures and AUD codes does not permit bivariate associations; n/a=not applicable