Table 1.
Characteristics of Adult Survivors of Childhood Cancer in the St Jude Lifetime (SJLIFE) Cohort
| Characteristics | N (%) or Mean (SD) |
|---|---|
| Cancer and Treatment Exposure | |
| Cancer diagnosis, N (%) | |
| Leukemia | 952 (38.5) |
| Lymphoma | 488 (19.7) |
| Embryonal tumors | 324 (13.1) |
| Sarcoma | 311 (12.6) |
| Central nervous system tumors | 229 (9.3) |
| Other | 172 (7.0) |
| Age at diagnosis, years, mean (SD) | 8.3 (5.6) |
| Time from diagnosis, years, mean (SD) | 24.1 (8.1) |
| Radiation therapy, N (%) | |
| Radiation (any) | 1,487 (60.0) |
| Head/neck only | 664 (26.8) |
| Head/neck + chest | 158 (6.4) |
| Head/neck + chest + abdomen/pelvis | 442 (17.8) |
| Chest +/− abdomen/pelvis | 172 (6.9) |
| Chemotherapy, N (%) | |
| Alkylating agents | 1,567 (63.2) |
| Anthracyclines | 1,444 (58.2) |
| Antimetabolites | 1,320 (53.2) |
| Glucocorticoids | 1,226 (49.4) |
| Demographics | |
| Age at study enrollment, years, mean (SD) | 32.3 (8.3) |
| Sex, N (%) | 1,275 (51.4) |
| Men | 1,205 (48.6) |
| Women | |
| Race/ethnicity, N (%) | |
| Non-Hispanic White | 2,076 (83.7) |
| Non-Hispanic Black | 321 (12.9) |
| Other | 83 (3.3) |
| Education, N (%) | |
| Grades 0–12 | 665 (28.3) |
| Some post high school | 781 (33.2) |
| College graduate | 905 (38.5) |
| Marital status, N (%) | |
| Married | 1,006 (40.6) |
| Other | 1,474 (59.4) |
| Lifestyle Factors | |
| Health Eating Index-2015, mean (SD) | 60.1 (10.9) |
| Physical activity*, N (%) | |
| Active | 1,241 (50.5) |
| Inactive | 1,215 (49.5) |
| Body mass index (BMI), kg/m2, mean (SD) | 28.5 (7.4) |
| Weight status, N (%) | |
| Underweight (BMI < 18.5) | 84 (3.4) |
| Normal weight (BMI =18.5–24.9) | 807 (32.8) |
| Overweight (BMI =25–29.9) | 704 (28.6) |
| Obese (BMI ≥30) | 868 (35.2) |
| Smoking, N (%) | |
| Nonsmokers | 1,621 (65.6) |
| Former smokers | 284 (11.5) |
| Current smokers | 565 (22.9) |
| Alcohol, drink/week, N(%) | |
| Nondrinkers | 1,176 (47.9) |
| Moderate | 1,038 (42.3) |
| High | 239 (9.7) |
| Adherence scores to healthy lifestyle behaviors, N(%) | |
| 0–2 | 568 (22.9) |
| 3 | 685 (27.6) |
| 4 | 651 (26.3) |
| 5 | 423 (17.1) |
| 6 | 153 (6.2) |
*
Minutes per week of moderate-to-vigorous physical activity (MVPA) were calculated by summarizing minutes, with vigorous physical activities weighted at 1.67 minutes for each minute of vigorous physical activity. Participants were classified as physically active if MVPA met or exceeded 150 minutes per week, according to the Center for Disease Control and Prevention (CDC) Physical Activity Guidelines for Americans.15
+
Moderate alcohol intake was defined as ≤ 1 drink/day for women and ≤ 2 drinks/day for men; and high alcohol intake was defined as > 1 drink/day for women and >2 drinks/day for men, according to the Dietary Guidelines for Americans.16