Table 4.
Patients with glomerular damage
| Sex | Age at last follow-up (years) | Mitochondrial disease diagnosis | Age at first symptom (years) | First symptom | Age at diagnosis (years) | Multisystem involvement | Age at diagnosis of renal impairment (years) | Renal involvement | GFR (mL/min/1.73 m2) | Uric (mg/dL) | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 9 | M | 7.7 | DMRCC IV | 0.5 | Hypotony | 1 | Encephalomyopathy Malnutrition Hearing loss Strabismus |
1 | CKD | 27 (N > 90) | 9.7 (2–5.1) |
| 10 | F | 1 | DMRCC I + IV Leigh syndrome |
0.6 | Psychomotor regression | 1 | Encephalomyopathy | 0.8 | CKD | 57 (N > 78) | 4.9 (2–5.1) |
| 11 | M | 8.1 | Leigh syndrome | 1 | Psychomotor delay | 2.2 | Ataxia Ptosis |
8.1 | Hyperuricemia | 121 (N > 90) | 5.9 (2–5.1) |
| 12 | F | 15.6 | DMRCC III + IV | 1 | Psychomotor delay | 3.3 | Encephalomyopathy Cerebellar atrophy Short stature |
15 | Low proteinuria Microhematuria | 300 (N > 90) | 5.2 (2.8–6) |
| 13 | M | 6.7 | DMRCC I, II + III | 4 | Hematuria | 6.7 | Epilepsy Autism spectrum disorder |
4 | Hematuria | 123 (N > 90) | 3.3 (2–5.1) |
F female, M male, DMRCC deficit mitochondrial respiratory chain complex, CKD chronic kidney disease, N normal range