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. 2018 Nov 9;8:16599. doi: 10.1038/s41598-018-34985-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Survival curves of Kudu infected with a high dose (black solid line) and low dose (black dashed line), contact animals from the transmission group (red line) and the Kudu vaccinated by direct oral application (DOA, blue line). The median incubation period for high and low dose infected Kudus was 13.5 days and 233 days, respectively. Among animals from the DOA group that succumbed to rabies the median incubation period was 15 days. The difference in the survival of vaccinated vs. high dose infected animals from the transmission study was below the statistical level of significance (Log-rank/Mantel-Cox test, p = 0.0786).