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. 2018 Nov 9;9:4725. doi: 10.1038/s41467-018-07171-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Tangential migration of iSPN in the striatal mantle. a Schematic coronal hemisection of a Drd2-EGFP + slice illustrating the area where multi-photon time-lapse imaging was performed. b–e Sample image (b, c with superimposed trajectories of individual cells) from a video tracking of iSPN migration allowing the identification of cell trajectory and directionality (c), saltatory behavior (d), and multidirectional displacement vectors (e; colors illustrate directionality). f–i Analysis of all tracked iSPN (n = 61 cells, n = 4 independent experiments) shows a moderate average net speed (f, 21.3 ± 1 μm/h), a high maximum speed (g, 124.8 ± 5 μm/h) and strong persistence (h, 74 ± 15%, ratio between net displacement speed and total distance traveled). i Analysis of mean directionality shows that iSPN migrate tangentially within the striatal mantle (color code similar to c and e). Results are presented as mean ± s.e.m. Scale bar equals 30 μm. D dorsal, L lateral, LGE lateral ganglionic eminence, M medial, Str striatum, V ventral