Table 2.
Results of orthogonal partial least squares discriminant analysis for the 1–23 month old cohorts.
| Patient cohort | Data | R2Y | Q2 | CV-ANOVA p-value | Sensitivity: Specificity | PPV:NPV | Accuracy | AUROC ± standard error |
|---|---|---|---|---|---|---|---|---|
| PICU-sepsis versus PED-sepsis |
Metabolites | 0.48 | 0.44 | 8.5 × 10−13 | 0.71:0.93 | 0.88:0.82 | 0.84 | 0.90 ± 0.03 |
| Mediators | 0.37 | 0.32 | 3.0 × 10−8 | 0.56:0.87 | 0.76:0.73 | 0.74 | 0.84 ± 0.04 | |
| Combined | 0.45 | 0.39 | 2.5 × 10−10 | 0.70:0.91 | 0.84:0.82 | 0.83 | 0.87 ± 0.04 | |
| PED-sepsis versus PED-controls |
Metabolites | 0.72 | 0.61 | 7.8 × 10−9 | 0.91:1.0 | 1.0:0.86 | 0.94 | 0.99 ± 0.01 |
| Mediators | 0.77 | 0.75 | 1.2 × 10−14 | 0.97:0.94 | 0.97:0.94 | 0.96 | 0.99 ± 0.003 | |
| Combined | 0.80 | 0.70 | 1.6 × 10−11 | 1.0:0.94 | 0.97:1.0 | 0.98 | 0.99 ± 0.02 | |
| PICU-sepsis versus PED-controls |
Metabolites | 0.93 | 0.88 | 1.9 × 10−14 | 1.0:1.0 | 1.0:1.0 | 1.0 | 1.0 |
| Mediators | 0.86 | 0.67 | 2.7 × 10−7 | 0.89:0.94 | 0.94:0.89 | 0.92 | 0.99 ± 0.01 | |
| Combined | 0.94 | 0.90 | 7.6 × 10−15 | 1.0:1.0 | 1.0:1.0 | 1.0 | 1.0 |
AUROC: area under the receiver operating characteristic curve; PICU: pediatric intensive care unit; PED: emergency department; R2Y: percentage of variation explained by the model; Q2: predictive ability of the model; CV-ANOVA: cross-validated analysis of variance; PPV:NPV: positive predictive value: negative predictive value.