Table 6.
The list of impaired metabolic pathways differentiating sepsis requiring care in pediatric intensive care from sepsis cared for in the emergency department.
| Metabolic pathway | p-value | Impact | Total | Hits |
|---|---|---|---|---|
| Pyruvate metabolism | 3.7 × 10−22 | 0.1 | 32 | Acetate |
| Alanine, aspartate and glutamate metabolism | 3.6 × 10−12 | 0.06 | 24 | Alanine |
| Sulfur metabolism | 3.7 × 10−22 | 0.03 | 18 | Acetate |
| Taurine and hypotaurine metabolism | 2.2 × 10−37 | 0.03 | 20 | Acetate, alanine |
| Fructose and mannose metabolism | 2.2 × 10−4 | 0.03 | 48 | Mannose |
| Selenoamino acid metabolism | 2.2 × 10−37 | 0.003 | 22 | Acetate, alanine |
The p-value was calculated during the pathway enrichment analysis and was adjusted by Holm-Bonferroni method. The pathway Impact value was calculated from the pathway topology analysis as the sum of the importance measures of the matched metabolites normalized by the sum of the importance measures of all metabolites in each pathway. The Total is the total number of compounds in the pathway and the Hits show the actually matched metabolites detected as potentially important compounds in our study. The analysis was performed using the MetaboAnalyst 3.0 software22.