Table 2.
Statistical analysis: Binary logistic (*) and linear regression analysis with the frequency of p62/SQSTM1-BD inclusions as dependent variable.
| n | Age in years | Gender (M/F) | Atrial fibrillation (y/n) | Arterial hypertension (y/n) | Myocardial infarction (y/n) | Heart weight/g | Degree of cardiac fibrosis | Degree of cardiac fibrosis in hypertensive individuals | Diabetes mellitus (y/n) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 62 | 62 | 51 | 62 | 62 | 62 | 62 | 62 | 62 | |||
| p62/SQSTM1-positive BD inclusions: binary logistic (*) and linear regression (only one independent variable) | β = 0.273; p = 0.032; R ² = 0.074 | p = 0.469* | p = 0.055* | p = 0.065* | p = 0.922* | p = 0.094 | β = 0.270; p = 0.033; R ² = 0.073 | β = 0.332; p = 0.008; R ² = 0.11 | p = 0.652* | ||
| p62/SQSTM1-positive BD inclusions: linear regression controlled for age and gender | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | p = 0.203 | β = 0.302; p = 0.032; R ² = 0.163 | n.d. | ||
| p62/SQSTM1-positive BD inclusions: linear regression controlled for myocardial infarction and heart weight | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.329; p = 0.009; R ² = 0.156 | n.d. | ||
| p62/SQSTM1-positive BD inclusions: linear regression controlled for diabetes mellitus, obesity and atrial fibrillation | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | p = 0.17 | n.d. | ||
| p62/SQSTM1-positive BD inclusions: linear regression controlled for CAA severity | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.304; p = 0.004; R ² = 0.233 | n.d. | ||
| p62/SQSTM1-positive BD inclusions: linear regression controlled for age, gender, and cardiac fibrosis in hypertensive individuals | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.367; p = 0.007; R ² = 0.26 | n.d. | ||
| p62/SQSTM1-positive BD inclusions: linear regression controlled for myocardial infarction, heart weight, and cardiac fibrosis in hypertensive individuals | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.333; p = 0.005; R ² = 0.267 | n.d. | ||
| n | Hyperlipoproteinemia (y/n) | Obesity (y/n) | Intracerebral hemorrhage (y/n) | Cerebral infarction (y/n) | Athersclerosis in CaW (% of affected vessels) | Stage of SVD | Severity grade of CAA | Aβ-phase (MTL) | Braak NFT-stage | CERAD-score | NIA-AA degree of AD |
| 38 | 38 | 62 | 62 | 59 | 62 | 62 | 62 | 62 | 62 | 62 | |
| p62/SQSTM1-positive BD inclusions: binary logistic (*) and linear regression (only one independent variable) | p = 0.488* | p = 0.404* | p = 0.247* | p = 0.181* | p = 0.161 | p = 0.545 | β = 0.340; p = 0.007; R ² = 0.116 | p = 0.094 | p = 0.166 | p = 0.137 | p = 0.072 |
| p62/SQSTM1-positive BD inclusions: linear regression controlled for age and gender | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.273; p = 0.035; R ² = 0.16 | n.d. | n.d. | n.d. | n.d. |
| p62/SQSTM1-positive BD inclusions: linear regression controlled for myocardial infarction, degree of myocardial fibrosis and heart weight | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.337; p = 0.006; R ² = 0.166 | n.d. | n.d. | n.d. | n.d. |
| p62/SQSTM1-positive BD inclusions: linear regression controlled for diabetes mellitus, arterial hypertension and atrial fibrillation | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.306; p = 0.026; R ² = 0.137 | n.d. | n.d. | n.d. | n.d. |
| p62/SQSTM1-positive BD inclusions: linear regression controlled for myocardial fibrosis in hypertensive individuals | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.308; p = 0.003; R ² = 0.233 | n.d. | n.d. | n.d. | n.d. |
| p62/SQSTM1-positive BD inclusions: linear regression controlled for age, gender, and cardiac fibrosis in hypertensive individuals | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.334; p = 0.008; R ² = 0.26 | n.d. | n.d. | n.d. | n.d. |
| p62/SQSTM1-positive BD inclusions: linear regression controlled for myocardial infarction, heart weight, and cardiac fibrosis in hypertensive individuals | n.d. | n.d. | n.d. | n.d. | n.d. | n.d. | β = 0.339; p = 0.005; R ² = 0.267 | n.d. | n.d. | n.d. | n.d. |
The independent variables are the variables in the respective columns and the control variables are provided for each line. n provides the number of cases available for the variables in the columns used to calculate linear regression analysis.
Statistical analysis of the effects on BD by age, gender, cardiac and AD-related pathologies and parameters, arterial hypertension, diabetes mellitus, atherosclerosis in the circle of Willis (CaW), cerebral small vessels disease (SVD), CAA by binary logistic (*) or linear regression analysis. R² reflects the degree in how far a respective model term of independent variables explains the dependent variable. β represents the standardized β-coefficient for each individual independent variable. Abbreviations: m/f Male/Female.