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. 2018 Nov 9;8:16626. doi: 10.1038/s41598-018-34761-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intervention effect on OTU composition. Change in relative abundance (% increase/decrease in geometric mean) of core OTUs during the neutral water (A) and alkaline (B) water interventions. Red dotted line indicates the cut-off corresponding to a Q-value of 0.05, and the blue dotted line indicates a P-values of 0.05. Prevalence indicates number of participants in which a given OTU is present in at least one sample. Abundance indicates mean relative abundance (‰) of a given OTU in baseline samples. Taxonomy of OTUs [Greengenes ID] is given at the lowest classified rank. o, order. f, family. g, genus.