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. 2018 Nov 9;8:16593. doi: 10.1038/s41598-018-34730-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The normalized Hamming distance (HD) estimates the distance of pathway topology through enzymatic reactions between cassava (MeRecon) and the other six model plants represented as heatmap in blue color. CAL - Calvin cycle, SUC - sucrose biosynthesis, STA - starch biosynthesis, RES - respiration, AMI - amino acid biosynthesis, CEL - cell wall biosynthesis, FAT - fatty acid biosynthesis, and NUC - nucleotide biosynthesis. The heatmap in red represents the HD scores that contrasted the topology of the overall carbon assimilation pathway of cassava (MeRecon) with the other plant species.