Table 4.
Comparison of clinicopathologic characteristics between patients with low NLR and high NLR; low PNI and high PNI.
| Factors | Low NLR <2.5 | High NLR >2.5 | P | Low PNI <40 | High PNI >40 | P |
|---|---|---|---|---|---|---|
| n = 77 | n = 41 | n = 48 | n = 70 | |||
| Age, years | 68.7 ± 10.6 | 70.7 ± 10.1 | 0.334 | 68.4 ± 10.9 | 70.1 ± 10.1 | 0.395 |
| Gender, male | 47 (61) | 27 (66) | 0.691 | 28 (48) | 46 (66) | 0.44 |
| Diabetes mellitus | 28 (36) | 23 (56) | 0.051 | 25 (52) | 26 (37) | 0.131 |
| End-stage renal disease | 4 (5) | 4 (10) | 0.446 | 4 (8) | 4 (6) | 0.714 |
| HBsAg positive | 20 (26) | 12 (29) | 0.828 | 17 (35) | 15 (21) | 0.139 |
| Anti-HCV positive | 60 (78) | 28 (68) | 0.273 | 34 (71) | 54 (77) | 0.52 |
| Major tumor size (≥3 cm) | 13 (17) | 14 (34) | 0.040 | 10 (21) | 17 (24) | 0.824 |
| Tumor stage II | 23 (30) | 7 (17) | 0.183 | 12 (25) | 18 (26) | 1 |
| AFP (>200 ng/mL) | 3 (4) | 5 (12) | 0.124 | 3 (6) | 5 (7) | 1 |
| AST (U/L) | 66.6 ± 47.9 | 48.1 ± 31.5 | 0.027 | 73.1 ± 49.3 | 51.3 ± 37.2 | 0.007 |
| ALT (U/L) | 62.4 ± 56.7 | 47.5 ± 52.4 | 0.164 | 61.0 ± 58.6 | 54.7 ± 53.6 | 0.547 |
| Child-Pugh class A | 60 (78) | 27 (66) | 0.189 | 20 (42) | 67(96) | <0.001 |
| Albumin (g/dL) | 3.6 ± 0.6 | 3.6 ± 0.6 | 0.862 | 3.0 ± 0.4 | 4.0 ± 0.4 | <0.001 |
| Total serum bilirubin(mg/dL) | 1.2 ± 0.6 | 1.1 ± 0.5 | 0.456 | 1.4 ± 0.7 | 1.0 ± 0.4 | <0.001 |
| INR | 1.1 ± 0.1 | 1.1 ± 0.1 | 0.906 | 1.2 ± 0.1 | 1.1 ± 0.1 | <0.001 |
| Ascites | 9 (12) | 12 (29) | 0.023 | 16 (33) | 5 (7) | <0.001 |
| WBC (×103/uL) | 4.5 ± 1.7 | 5.3 ± 2.1 | 0.035 | 3.9 ± 1.7 | 5.4 ± 1.7 | <0.001 |
| Neutrophil count (%) | 52.8 ± 7.9 | 69.6 ± 5.9 | <0.001 | 58.6 ± 10.8 | 58.6 ± 11 | 0.996 |
| Lymphocyte count (%) | 34.8 ± 7.3 | 19.7 ± 4.5 | <0.001 | 29.0 ± 9.8 | 29.9 ± 9.6 | 0.606 |
| Platelet count (103/μL) | 118.9 ± 58.2 | 130.5 ± 95.1 | 0.415 | 89.7 ± 45.4 | 145.7 ± 79.6 | <0.001 |
NLR, neutrophil-to-lymphocyte ratio; PNI, prognostic nutritional index; HBsAg, hepatitis B surface antigen; HCV, hepatitis C virus; AFP, α-fetoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; INR, international normalized ratio of prothrombin time; WBC, white blood cell count.