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. 2018 Nov 9;8:16598. doi: 10.1038/s41598-018-33773-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diagrammatic illustration of Trans-domain species found in the tested subjects. An overall number of Trans-domain species (eubacteria, archaea, fungi, and microeukaryotes) in HLT and KSD subjects were demonstrated and presented only on presence or absence data through igraph. The Tran-domain species which were uniquely distributed in either HLT or KSD subjects are represented by red (HLT), blue (KSD) and violet color for common species.