Table 1.
Cluster analysis of differentially expressed circular RNAs.
| Cluster | circType | host gene | 0 h vs 1 h (T) | 0 h vs 1 h (U) | 1 h (T vs U) | 2 h (T vs U) | 4 h (T vs U) | 6 h (T vs U) |
|---|---|---|---|---|---|---|---|---|
| 1 | circRNA | FNDC3B | 2.87 | −0.58 | 3.46 | 0.00 | 0.00 | 0.00 |
| 2 | circRNA | DLG1 | 2.32 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
| 3 | circRNA | AGRN | 1.00 | 4.95 | −3.95 | 0.00 | 0.00 | 0.00 |
| 4 | circRNA | FLNA | 0.00 | 2.17 | 0.00 | −2.54 | 0.00 | 0.00 |
| 5 | circRNA | EIF4G1 | 0.00 | 3.09 | 0.00 | 0.00 | 0.00 | 0.00 |
| circRNA | FLNA | 0.00 | 3.17 | 0.00 | 0.00 | 0.00 | 0.00 | |
| 6 | circRNA | GNB2L1 | 0.00 | −2.32 | 0.00 | 0.00 | 0.00 | 0.00 |
| circRNA | RPLP0 | 0.00 | −2.32 | 0.00 | 0.00 | 0.00 | 0.00 | |
| 7 | circRNA | GAPDH | 0.00 | 0.00 | 2.81 | 0.00 | 0.00 | 0.00 |
| 8 | circRNA | TNS3 | 0.00 | 0.00 | −3.81 | 0.00 | 0.00 | 0.00 |
| 9 | circRNA | TNIK | 0.00 | 0.00 | 0.00 | 2.81 | 0.00 | 0.00 |
| 10 | circRNA | NBPF12 | −0.22 | 0.89 | −1.12 | −2.38 | 1.74 | 0.51 |
| 11 | circRNA | CRIM1 | 0.00 | 0.00 | 0.00 | 0.00 | 2.58 | 0.00 |
| circRNA | FN1 | 0.00 | 0.00 | 0.00 | 0.00 | 2.58 | 0.00 | |
| circRNA | RBMS3 | 0.00 | 0.00 | 0.00 | 0.00 | 2.32 | 0.00 | |
| 12 | circRNA | PHC3 | 0.00 | 0.00 | 0.00 | 0.00 | −2.32 | 0.00 |
| 13 | ciRNA | TXNRD1 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 3.17 |
| circRNA | ANKRD36C | 0.00 | 0.00 | 0.00 | 0.00 | 0.58 | 2.70 | |
| circRNA | SMC4 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.32 | |
| circRNA | UBXN4 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 2.32 | |
| 14 | circRNA | VIM | −2.00 | 0.00 | −2.00 | 1.22 | 0.00 | −2.81 |
All significant differentially expressed circular RNAs were clustered by similarity of fold change trends. Italic FCs represent selected up–regulated circRNAs (FC > 2), while bold ones indicate down–regulated circRNAs (FC < −2, considering the replacement of original FC value by its negative reciprocal value, in order to make the variation more noticeable). T = Treated sample. U = Untreated sample.