Table 1.
Effect of pretreatment of CurNisNp on heart rate and ECG parameters in MI induced guinea pigs.
| HR (min) | P (ms) | PR int (ms) | QRS (ms) | QT int (ms) | QTc | R-amp (mV) | |
|---|---|---|---|---|---|---|---|
| Group A | 267.0 ± 7.8 | 25.0 ± 6.57 | 61.00 ± 2.56 | 32.33 ± 6.74 | 111.0 ± 21.03 | 234.0 ± 37.54 | 0.39 ± 0.12 |
| Group B | 237.0 ± 8.5a++ | 24.00 ± 7.00 | 52.50 ± 2.50a++ | 26.50 ± 1.50a | 156.5 ± 9.50a | 299.5 ± 5.50a | 1.27 ± 0.07a++ |
| Group C | 255.0 ± 10b+ | 26.00 ± 2.00 | 62.50 ± 2.50b++ | 30.50 ± 3.50b | 165.5 ± 6.50a | 327.0 ± 1.00 a | 0.45 ± 0.11b++ |
| Group D | 249.5 ± 4.5a,b | 22.50 ± 6.50 | 62.00 ± 1.00b++ | 27.00 ± 5.00 | 128.0 ± 12.0b | 260.5 ± 21.50b | 0.33 ± 0.07b++ |
| Group E | 253.5 ± 11.5b | 24.00 ± 3.00 | 61.00 ± 1.00b++ | 35.00 ± 5.00b+ | 132.5 ± 21.5b | 255.0 ± 28.00b | 0.66 ± 0.31b++ |
Note; HR, heart rate; P, PR, QRS and QT are durations on the ECG wave form; QTc, corrected QT interval; R-amp, R-wave amplitude. The results in the table above are in Mean ± standard deviation of each group of five guinea pigs. aP < 0.05 compared with group A; a++P < 0.001 compared with group A; bP < 0.05 compared with group B; b+P < 0.01 compared with group B; b++P < 0.001 compared with group B.