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. 2018 Dec;367(3):393–404. doi: 10.1124/jpet.118.251652

TABLE 1.

Pharmacokinetic parameters for ketamine and metabolites in plasma and brain tissue of male and female rats

Parameter kel t1/2 Tmax Cmax AUC0-t AUC0-∞ AUMC0-t AUMC0-∞ MRT0-t MRT0-∞ Vz/F Cl/F
1/min min min ng/ml ng•min/l ng•min/l ng•min2/l ng•min2/l min min l/kg (l/min)/kg
Plasma
 Netamine
  Male 0.0156 44.42 5 100.52 2.86 3.10 127.52 186.09 44.60 60.05 51.69 0.807
  Female 0.0116 59.99 5 135.83 5.48 6.07 276.24 434.03 50.45 71.53 35.66 0.412
 Norketamine
  Male 0.0124 55.76 30 190.68 14.54 16.85 808.15 1409.02 55.58 83.63 11.94 0.148
  Female 0.0095 72.72 30 311.80 28.04 34.41 1937.45 3751.16 69.10 109.03 7.62 0.073
 Dehydronorketamine
  Male — — 30 9.88 0.61 — 38.48 — 62.67 — — —
  Female — — 90 5.49 0.66 — 62.28 — 94.02 — — —
mPFC
 Ketamine
  Male 0.0471 14.72 5 198.47 9.09 — 288.26 — 31.72 — — —
  Female 0.0504 13.74 10 402.87 10.92 — 274.57 — 25.15 — — —
 Norketamine
  Male 0.0223 31.08 10 170.64 9.78 — 405.59 — 41.45 — — —
  Female 0.0170 40.66 10 413.26 26.07 — 1233.84 — 47.33 — — —
HPC
 Ketamine
  Male 0.0487 14.24 10 199.21 9.12 — 289.12 — 31.70 — — —
  Female 0.0503 13.78 10 375.79 10.72 — 277.72 — 25.91 — — —
 Norketamine
  Male 0.0239 29.01 10 170.25 9.10 — 355.52 — 39.06 — — —
  Female 0.0163 42.42 10 374.46 21.69 — 1043.47 — 48.12 — — —

AUMC, area under the first moment concentration-time curve; Tmax, time to reach Cmax; MRT, mean residence time; —, n/a.