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Antisense oligonucleotide prevents the exercise-induced increase in SOD2 activity and protein abundance without altering CSA and diaphragm muscle force. A) ELISA of diaphragm SOD2 protein abundance, n = 10, B) SOD2 activity, n = 8, C) diaphragm CSA, n = 10, and D) force frequency curve, n = 10. Values are mean percent change of control ± SE. CON, control (dotted line is representative control value); Ex, exercise; Ex-AS, exercise with antisense. * p < 0.05 Ex is different from Ex-AS.
