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. 2018 Oct 21;20:402–413. doi: 10.1016/j.redox.2018.10.005

Fig. 9.

Fig. 9

Transgenic overexpression of SOD2 in the diaphragm alters proteolytic pathways. A) Diaphragm αII-spectrin degradation was used as an assessment of calpain activity from experiment 2, Representative image of αII-spectrin and total protein, n = 8/group. B) αII-spectrin protein degradation from experiment 2, n = 8/group. C) MuRF1 mRNA expression from experiment 2, n = 6/group. D) Atrogin-1 mRNA expression, n = 6/group. E) Diaphragm LC3 II was used as a marker of autophagosome formation in experiment 2. Representative image of LC3 II and total protein. F) LC3 II protein from experiment 2 n = 8/group. Values are mean percent change of control ± SE. *p < 0.05 different from CON, # p < 0.05 different from SOD2OvExp, δ p < 0.05 different from all groups.