Table 1.

Serum Concentrations of Steroids in a Reference Population of Girls Between Ages 4 and 10 Years

Steroid, ng/dL	Aged 4–5 y (n = 22)	Aged 6–8 y (n = 38)	Aged 9–10 y (n = 23)
Unconjugated 21-carbon steroids
Pregnenolone	26.3 [14.9–38. 9]	21.45 [14.5–31.7]	25.9 [19.8–40.5]
17OH-Pregnenolone	ND	ND	ND
Progesterone	5.3 [5.0–7.7]	5.1 [4.4–6.1]	4.7 [4.2–6.6]
17OH-Progesterone	17.4 [10.9–28.2]	15.4 [12.8–21.8]	22.3 [13.5–34.2]
11-Deoxycorticosterone	17.3 [8.0–44.4]	7.62 [5.03–19.77]a	8.1 [4.3–18.0]a
Corticosterone	145.4 [85.2–295.1]	113.5 [66.0–232]	84.2 [70.5–221]
11-Deoxycortisol	45.9 [26.6–62.7]	35.5 [22.4–51.1]	35.5 [26.3–52.4]
Cortisol	5481 [3562–9561]	4457 [3504–7100]	4361 [3212–9106]
Unconjugated 19-carbon steroids
DHEA	41.3 [23.0–54.7]	64.2 [43.5–141.4]a	134 [84.1–186]a,b
A4	10.4 [8.4 –15.2]	15.5 [10.3–24.7]	21.2 [19.1–28.6]a,b
T	3.8 [2.4–4.9]	4.8 [4.2–5.3]a	6.3 [5.2–8.1]a,b
11OHA4	17.6 [11.2–34.0]	27.0 [20.0–39.7]	26.1[17.4–44.8]
11KA4	8.18 [6.77–11.23]	11.3 [9.90–14.47]a	12.8 [8.7–16.8]a
11OHT	3.0 [2.6–6.5]	4.6 [3.2–6.7]	5.5 [4.1–6.5]a
11KT	8.6 [7.3–10.9]	13.4 [10.3–18.1]a	17.6 [14.2–22.5]a,b
Sulfated steroids
Preg-S	934 [555–1462 ]	1029 [718–1338]	1435 [975–2243]
17OHPreg-S	347 [257–614]	445 [370–712]	645 [507–1003]a
DHEA-S	5902 [3545–10,231]	13,750 [7672–34,899]a	34,604 [27,308–50,856]a,b
Adiol-S	527 [387–1228]	1149 [663–2464]a	2958 [1943–5540]a,b

Data are expressed as median with corresponding interquartile range. Statistical significance was determined by Kruskal-Wallis one-way ANOVA followed by the Dunn post hoc test for multiple comparisons. Significance levels are indicated by the footnotes. Note: 17OH-Preg was detected (>172.6 ng/dL) in two subjects between ages 6–8 y and 9–10 y each.

Abbreviation: ND, not detected.

^a P < 0.05 vs age 4–5 y.

^b P < 0.05 vs age 6–8 y.