Table 2.

Serum Concentrations of Steroids in Girls With PremA vs Age-Matched Girls Between Ages 4 and 7 Years

Steroid, ng/dL	Age-Matched Girls (n = 54)	Girls With PremA (n = 37)	P Value
Unconjugated 21-carbon steroids
Pregnenolone	25.6 [14.6–46.2]	50.6 [32.8–83.4]	<0.001
17OH-Pregnenolone	ND	ND	—
Progesterone	5.3 [4.7–7.1]	2.7 [2.0–5.6]	<0.001
17OH-Progesterone	16.2 [12.8–26.3]	12.8 [9.5–22.1]	0.030
11-Deoxycorticosterone	9.7 [6.8–34.1]	7.9 [4.2–14.4]	0.008
Corticosterone	131 [82.8–220]	92.2 [50.4–218]	0.054
11-Deoxycortisol	40.5 [29.4–55.0]	30.4 [19.2–48.1]	0.025
Cortisol	5487 [3784–7873]	4911 [3352–6528]	0.089
Unconjugated 19-carbon steroids
DHEA	52.3 [32.8–89.5]	242 [162–429]	<0.001
A4	13.1 [9.2–22.4]	17.0 [11.4–22.8]	0.238
T	4.6 [3.7–5.2]	5.2 [4.6–5.8]	<0.001
11OHA4	26.1 [16.7–38.9]	45.7 [29.3–67.5]	<0.001
11KA4	10.8 [8.2–13.8]	15.0 [12.4–22.1]	<0.001
11OHT	3.8 [2.6–6.1]	6.2 [4.9–7.4]	<0.001
11KT	11.2 [8.4–16.5 ]	18.1 [12.3–22.9]	<0.001
Sulfated steroids
Preg-S	958 [582–1198]	1722 [1162–2124]	<0.001
17OHPreg-S	416 [270–605]	803 [564–1198]	<0.001
DHEA-S	9321 [4333–17637]	38,227 [23,035–57,073]	<0.001
Adiol-S	764 [450–1606 ]	4102 [2323–6660]	<0.001

Data are expressed as median with corresponding interquartile range. Statistical significance was determined by nonparametric Mann–Whitney U test. P < 0.05 was considered statistically significant. Note: 17OH-Preg was detected (>172.6 ng/dL) in only one reference subject between ages 4 and 7 y and no subjects with PremA.

Abbreviation: ND, not detected.