Table 2.

Cost and Disability Model Parameters

Parameter	Cost, 2016 $	Unit	Comment	Reference(s)
Direct costs
Conjugate Vi typhoid vaccine	2.50	Per vaccine schedule	One-dose schedule	[35]
EPI delivery (ages <1 y)	1.10	Per dose	One delivery	[30, 32–34]
School-based delivery (ages 5–14 y)	1.30	Per dose	One delivery	[31, 32]
Community-based delivery (ages 1–4 and >14 y)	1.50	Per dose	One delivery	[31, 32]
Indirect costs
Child (<15 y), outpatient	33.00	Per patient	…	[36]
Adult (≥15 y), outpatient	66.00	Per patient	…	[36]
Child (<15 y), inpatient	222.00	Per patient	9% admitted	[36]
Adult (≥15 y), inpatient	444.00	Per patient	27% admitted	[36]
Health state	Percentage of Case-Years (95% CI)	Disability Weight (95% CI)
Acute infectious disease, moderate	35.0 (26.0–44.3)	0.051 (.032–.074)		[28, 29]
Acute infectious disease, severe	47.75 (38.0–57.4)	0.133 (.088–.19)		[28, 29]
Abdominal pain and distension (including intestinal perforation)	17.0 (10.0–25.7)	0.324 (.22–.442)		[28, 29]
Gastrointestinal bleeding	0.25 (0–2.0)	0.325 (.209–.462)		[28, 29]

Abbreviations: CI, confidence interval; EPI, Expanded Program on Immunization.