Table 1.
Summary of the known kinases and phosphatases involved in chromosome structure regulation.
| Kinases | Function | Phosphatases | Function | |
|---|---|---|---|---|
| Chromatin condensation | CDK1 | Anchoring site for PLK1 | PP2A | Condensin II binding to chromatin |
| PLK1 | Condensin II binding to chromatin | PNUTS/PP1 | Chromosome de-condensation | |
| Aurora B | Condensin I binding to chromatin | Repo-man/PP1 | Chromosome de-condensation | |
| Telomeres | ATM (Tel1) | Recruitment of telomerase to telomeres | Rif1/PP1 | Inhibits Tel1 recruitment |
| DNA-PK | Telomeres protection | PP2A | Inhibits telomerase recruitment to telomeres | |
| Chromosome periphery | CDK1 | Phosphorylation of perichromosomal proteins | Ki-67/PP1 | Required for chromosome periphery formation |
| CK-II | ||||
| PLK1 | ||||
| Centromeres/kinetochore | CDK1 | Block CENP-A deposition to centromeres | PP1 | Enhance CENP-A deposition on centromeres |
| Aurora A | ||||
| Aurora B |