Table 1.
Global death and YLL numbers, age-standardised rates per 100 000, and percentage change between 2007 and 2017 for both sexes combined for all GBD causes and Levels 1 through 4 of the cause hierarchy
|
All-age deaths (thousands) |
Age-standardised death rate (per 100 000) |
All-age YLLs (thousands) |
Age-standardised YLL rate (per 100 000) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 2017 | Percentage change, 2007–17 | 2017 | Percentage change, 2007–17 | 2017 | Percentage change, 2007–17 | 2017 | Percentage change, 2007–17 | |||
| All causes | 55 945·7 (55 356·4 to 56 516·7) | 9·3% (8·2 to 10·2)* | 737·7 (729·9 to 745·4) | −14·2% (−15·0 to −13·5)* | 1 646 249·6 (1 622 870·6 to 1 673 178·4) | −9·0% (−10·1 to −7·6)* | 21 926·4 (21 601·1 to 22 314·9) | −22·2% (−23·2 to −21·0)* | ||
| Communicable, maternal, neonatal, and nutritional diseases | 10 389·9 (10 004·0 to 10 975·9) | −22·2% (−24·0 to −20·0)* | 143·8 (138·4 to 151·6) | −31·8% (−33·3 to −30·1)* | 578 416·6 (558 815·0 to 600 759·1) | −30·4% (−32·4 to −28·2)* | 8280·6 (8005·4 to 8602·8) | −35·4% (−37·3 to −33·4)* | ||
| HIV/AIDS and sexually transmitted infections | 1073·6 (983·3 to 1182·4) | −47·7% (−50·0 to −45·1)* | 13·9 (12·6 to 15·5) | −53·6% (−55·8 to −51·0)* | 60 550·2 (53 533·7 to 69 156·3) | −47·3% (−50·2 to −44·0)* | 806·4 (703·1 to 936·7) | −52·1% (−55·2 to −48·6)* | ||
| HIV/AIDS | 954·5 (907·3 to 1009·7) | −50·3% (−52·1 to −48·3)* | 12·1 (11·5 to 12·9) | −56·5% (−58·0 to −54·7)* | 50 497·1 (47 658·0 to 53 595·8) | −51·2% (−52·9 to −49·2)* | 655·1 (617·5 to 696·4) | −56·6% (−58·1 to −54·8)* | ||
| HIV/AIDS and drug-susceptible tuberculosis co-infection | 194·6 (137·7 to 253·0) | −55·4% (−58·4 to −51·6)* | 2·5 (1·8 to 3·2) | −61·1% (−63·7 to −57·7)* | 10 664·8 (7613·4 to 13 757·1) | −55·6% (−58·7 to −51·7)* | 140·0 (100·2 to 180·0) | −60·5% (−63·1 to −57·0)* | ||
| HIV/AIDS and multidrug-resistant tuberculosis without extensive drug resistance co-infection | 22·6 (13·4 to 34·5) | −52·2% (−66·4 to −33·2)* | 0·3 (0·2 to 0·4) | −58·1% (−70·5 to −41·5)* | 1247·8 (746·6 to 1906·7) | −51·7% (−65·7 to −33·2)* | 16·4 (9·8 to 25·1) | −56·8% (−69·3 to −40·4)* | ||
| HIV/AIDS and extensively drug-resistant tuberculosis co-infection | 1·2 (0·8 to 1·8) | −8·3% (−26·8 to 14·7) | 0·0 (0·0 to 0·0) | −20·3% (−36·4 to −0·2)* | 62·7 (38·3 to 92·9) | −10·5% (−28·4 to 11·5) | 0·8 (0·5 to 1·2) | −21·0% (−36·7 to −1·4)* | ||
| HIV/AIDS resulting in other diseases | 736·0 (659·5 to 817·7) | −48·7% (−51·1 to −45·9)* | 9·3 (8·4 to 10·4) | −55·1% (−57·2 to −52·6)* | 38 521·8 (34 381·3 to 43 095·5) | −49·8% (−52·3 to −46·9)* | 497·9 (444·2 to 558·4) | −55·4% (−57·6 to −52·8)* | ||
| Sexually transmitted infections excluding HIV | 119·1 (50·8 to 220·4) | −10·8% (−18·4 to −2·5)* | 1·8 (0·7 to 3·3) | −14·4% (−21·5 to −6·6)* | 10 053·1 (4057·0 to 18 915·2) | −11·4% (−19·0 to −3·2)* | 151·3 (60·6 to 285·3) | −14·4% (−21·8 to −6·6)* | ||
| Syphilis | 113·5 (45·2 to 214·5) | −11·3% (−19·1 to −2·8)* | 1·7 (0·7 to 3·2) | −14·3% (−21·8 to −6·4)* | 9836·1 (3848·5 to 18 676·4) | −11·5% (−19·3 to −3·1)* | 148·6 (58·0 to 282·3) | −14·3% (−21·8 to −6·2)* | ||
| Chlamydial infection | 1·1 (0·9 to 1·2) | 2·5% (−4·5 to 11·3) | 0·0 (0·0 to 0·0) | −15·2% (−21·0 to −8·4)* | 40·5 (32·6 to 45·0) | −5·5% (−12·2 to 2·5) | 0·5 (0·4 to 0·6) | −17·9% (−23·7 to −11·0)* | ||
| Gonococcal infection | 3·0 (2·4 to 3·3) | 3·7% (−3·4 to 12·5) | 0·0 (0·0 to 0·0) | −14·9% (−20·8 to −8·2)* | 112·8 (90·2 to 124·9) | −3·8% (−10·7 to 4·3) | 1·4 (1·1 to 1·6) | −17·4% (−23·5 to −10·7)* | ||
| Other sexually transmitted infections | 1·5 (1·2 to 1·7) | 0·2% (−6·4 to 8·3) | 0·0 (0·0 to 0·0) | −15·9% (−21·6 to −9·5)* | 63·6 (51·0 to 70·7) | −6·2% (−12·7 to 1·1) | 0·8 (0·6 to 0·9) | −18·2% (−23·9 to −11·7)* | ||
| Respiratory infections and tuberculosis | 3752·3 (3629·4 to 3889·3) | −8·0% (−10·3 to −5·5)* | 50·5 (48·8 to 52·3) | −24·5% (−26·4 to −22·6)* | 148 233·5 (141 335·1 to 155 291·4) | −24·7% (−27·4 to −21·7)* | 2056·0 (1956·3 to 2160·7) | −32·8% (−35·4 to −30·0)* | ||
| Tuberculosis | 1183·7 (1129·8 to 1245·3) | −14·9% (−18·2 to −10·3)* | 14·9 (14·3 to 15·7) | −31·4% (−34·1 to −27·6)* | 41 876·9 (39 972·4 to 44 120·5) | −21·2% (−24·4 to −17·4)* | 533·4 (509·1 to 562·6) | −33·3% (−35·9 to −30·0)* | ||
| Drug-susceptible tuberculosis | 1044·1 (951·6 to 1129·2) | −15·5% (−22·3 to −8·6)* | 13·2 (12·0 to 14·2) | −31·9% (−37·3 to −26·4)* | 36 932·5 (33 846·8 to 39 919·1) | −21·9% (−27·8 to −16·0)* | 470·7 (431·3 to 508·4) | −33·8% (−38·7 to −29·0)* | ||
| Multidrug-resistant tuberculosis without extensive drug resistance | 126·9 (70·1 to 202·2) | −11·6% (−47·4 to 38·1) | 1·6 (0·9 to 2·5) | −28·6% (−57·4 to 11·4) | 4505·1 (2582·5 to 6984·6) | −17·6% (−49·4 to 26·5) | 57·2 (33·0 to 88·4) | −30·2% (−56·9 to 6·6) | ||
| Extensively drug-resistant tuberculosis | 12·6 (8·6 to 18·0) | 14·0% (−18·7 to 58·7) | 0·2 (0·1 to 0·2) | −7·7% (−34·1 to 28·8) | 439·2 (306·2 to 616·5) | 5·5% (−23·2 to 44·9) | 5·5 (3·8 to 7·7) | −11·1% (−35·2 to 22·1) | ||
| Lower respiratory infections | 2558·6 (2442·2 to 2655·4) | −4·3% (−6·9 to −1·5)* | 35·4 (33·8 to 36·8) | −21·1% (−23·2 to −18·9)* | 105 834·5 (99 746·4 to 111 767·8) | −25·9% (−29·2 to −22·2)* | 1515·1 (1424·8 to 1602·2) | −32·6% (−35·7 to −29·2)* | ||
| Upper respiratory infections | 9·1 (6·1 to 12·4) | −30·5% (−41·0 to −14·5)* | 0·1 (0·1 to 0·2) | −42·1% (−49·6 to −29·9)* | 477·3 (247·3 to 730·5) | −33·2% (−44·1 to −12·9)* | 6·9 (3·5 to 10·6) | −38·6% (−48·3 to −19·4)* | ||
| Otitis media | 0·9 (0·7 to 1·5) | −41·4% (−51·6 to −28·4)* | 0·0 (0·0 to 0·0) | −50·4% (−58·8 to −39·9)* | 44·8 (31·2 to 72·1) | −49·4% (−59·9 to −35·5)* | 0·6 (0·4 to 1·0) | −54·5% (−64·1 to −41·8)* | ||
| Enteric infections | 1766·0 (1398·0 to 2386·0) | −17·2% (−24·6 to −8·2)* | 24·4 (19·5 to 32·4) | −29·9% (−34·9 to −23·1)* | 84 625·5 (73 770·6 to 100 720·2) | −30·6% (−36·3 to −23·7)* | 1208·6 (1064·1 to 1424·7) | −36·6% (−41·8 to −30·7)* | ||
| Diarrhoeal diseases | 1569·6 (1176·0 to 2193·0) | −16·6% (−25·3 to −6·7)* | 21·6 (16·4 to 29·7) | −30·2% (−36·1 to −22·7)* | 70 574·3 (60 421·1 to 86 165·2) | −32·0% (−38·6 to −23·9)* | 1009·1 (870·5 to 1211·0) | −38·1% (−43·9 to −31·3)* | ||
| Typhoid and paratyphoid | 135·9 (76·9 to 218·9) | −22·3% (−27·3 to −18·1)* | 1·9 (1·1 to 3·0) | −27·8% (−32·8 to −23·9)* | 9686·1 (5484·9 to 15 746·2) | −23·8% (−29·3 to −19·4)* | 136·3 (77·0 to 220·9) | −28·7% (−34·0 to −24·4)* | ||
| Typhoid fever | 116·8 (65·4 to 187·7) | −23·7% (−29·0 to −19·3)* | 1·6 (0·9 to 2·6) | −29·1% (−34·1 to −25·0)* | 8331·7 (4632·5 to 13 419·2) | −25·3% (−31·0 to −20·8)* | 117·3 (65·5 to 188·5) | −30·1% (−35·6 to −25·7)* | ||
| Paratyphoid fever | 19·1 (8·7 to 37·3) | −12·7% (−20·1 to −4·2)* | 0·3 (0·1 to 0·5) | −18·9% (−26·1 to −10·8)* | 1354·4 (622·3 to 2620·2) | −13·2% (−21·3 to −3·8)* | 19·0 (8·8 to 36·6) | −18·6% (−26·5 to −9·7)* | ||
| Invasive non-typhoidal salmonella | 59·1 (33·3 to 98·1) | −17·9% (−25·1 to −8·7)* | 0·8 (0·5 to 1·4) | −24·8% (−31·9 to −15·6)* | 4260·8 (2382·0 to 7378·6) | −17·2% (−25·7 to −6·8)* | 61·6 (34·7 to 107·6) | −22·6% (−30·7 to −12·5)* | ||
| Other intestinal infectious diseases | 1·4 (1·0 to 2·2) | −39·7% (−67·1 to 9·7) | 0·0 (0·0 to 0·0) | −44·7% (−70·1 to 2·3) | 104·4 (67·8 to 170·7) | −43·6% (−71·6 to 11·9) | 1·5 (1·0 to 2·5) | −46·9% (−73·7 to 6·3) | ||
| Neglected tropical diseases and malaria | 720·1 (530·7 to 938·8) | −29·0% (−37·3 to −19·3)* | 10·1 (7·5 to 13·2) | −36·1% (−43·7 to −27·3)* | 48 656·2 (35 574·6 to 64 934·2) | −33·7% (−42·4 to −23·7)* | 699·9 (508·0 to 933·6) | −38·6% (−46·7 to −29·2)* | ||
| Malaria | 619·8 (440·1 to 839·5) | −30·8% (−39·4 to −20·8)* | 8·7 (6·1 to 11·9) | −37·3% (−45·4 to −27·9)* | 43 546·6 (29 966·3 to 59 772·4) | −34·5% (−43·8 to −23·6)* | 629·4 (432·6 to 858·7) | −39·2% (−48·2 to −28·8)* | ||
| Chagas disease | 7·9 (7·5 to 8·6) | 3·8% (−1·6 to 12·9) | 0·1 (0·1 to 0·1) | −21·1% (−25·2 to −14·3)* | 174·9 (166·1 to 193·5) | −4·2% (−9·0 to 4·8) | 2·2 (2·0 to 2·4) | −25·1% (−28·9 to −18·1)* | ||
| Leishmaniasis | 7·5 (0·0 to 34·5) | −64·8% (−96·8 to −44·5)* | 0·1 (0·0 to 0·5) | −67·8% (−97·5 to −50·3)* | 509·8 (0·3 to 2440·2) | −63·8% (−92·1 to −39·7)* | 7·2 (0·0 to 34·6) | −66·2% (−93·2 to −43·8)* | ||
| Visceral leishmaniasis | 7·5 (0·0 to 34·5) | −64·8% (−96·8 to −44·5)* | 0·1 (0·0 to 0·5) | −67·8% (−97·5 to −50·3)* | 509·8 (0·3 to 2440·2) | −63·8% (−92·1 to −39·7)* | 7·2 (0·0 to 34·6) | −66·2% (−93·2 to −43·8)* | ||
| African trypanosomiasis | 1·4 (0·3 to 4·9) | −80·7% (−95·6 to −27·8)* | 0·0 (0·0 to 0·1) | −82·8% (−96·0 to −34·3)* | 77·6 (15·0 to 283·6) | −80·8% (−95·6 to −27·2)* | 1·0 (0·2 to 3·8) | −82·3% (−96·0 to −33·6)* | ||
| Schistosomiasis | 8·8 (8·0 to 9·8) | −12·3% (−17·6 to −6·4)* | 0·1 (0·1 to 0·1) | −28·5% (−32·7 to −23·7)* | 342·3 (305·3 to 384·3) | −15·6% (−21·9 to −8·8)* | 4·4 (3·9 to 5·0) | −27·4% (−32·9 to −21·4)* | ||
| Cysticercosis | 0·7 (0·5 to 1·0) | −15·9% (−42·7 to 23·3) | 0·0 (0·0 to 0·0) | −27·3% (−50·5 to 5·3) | 39·6 (26·9 to 55·0) | −20·5% (−46·9 to 18·2) | 0·5 (0·4 to 0·7) | −28·9% (−52·5 to 4·8) | ||
| Cystic echinococcosis | 1·2 (0·9 to 1·5) | −30·0% (−52·1 to −1·3)* | 0·0 (0·0 to 0·0) | −41·9% (−59·8 to −19·0)* | 52·0 (38·1 to 68·0) | −38·8% (−56·8 to −12·9)* | 0·7 (0·5 to 0·9) | −46·4% (−62·0 to −24·1)* | ||
| Dengue | 40·5 (17·6 to 49·8) | 65·5% (21·7 to 99·7)* | 0·5 (0·2 to 0·7) | 40·7% (3·6 to 69·7)* | 1902·9 (716·6 to 2312·9) | 32·0% (−1·8 to 61·2) | 26·1 (9·8 to 31·7) | 18·2% (−12·0 to 45·0) | ||
| Yellow fever | 4·8 (1·0 to 13·8) | −16·6% (−28·7 to −2·0)* | 0·1 (0·0 to 0·2) | −23·3% (−34·4 to −9·6)* | 313·9 (67·2 to 900·2) | −16·0% (−28·9 to 0·0) | 4·3 (0·9 to 12·4) | −21·3% (−33·6 to −5·8)* | ||
| Rabies | 11·7 (9·3 to 14·7) | −48·1% (−58·8 to −37·3)* | 0·2 (0·1 to 0·2) | −54·8% (−63·8 to −45·0)* | 633·7 (504·4 to 836·4) | −51·5% (−61·3 to −38·9)* | 8·6 (6·8 to 11·5) | −56·2% (−65·1 to −44·3)* | ||
| Intestinal nematode infections | 3·2 (2·5 to 4·1) | −43·1% (−56·1 to −25·0)* | 0·0 (0·0 to 0·1) | −47·2% (−59·5 to −30·1)* | 257·1 (194·1 to 336·3) | −44·1% (−57·6 to −25·0)* | 3·8 (2·9 to 5·0) | −47·6% (−60·4 to −29·6)* | ||
| Ascariasis | 3·2 (2·5 to 4·1) | −43·1% (−56·1 to −25·0)* | 0·0 (0·0 to 0·1) | −47·2% (−59·5 to −30·1)* | 257·1 (194·1 to 336·3) | −44·1% (−57·6 to −25·0)* | 3·8 (2·9 to 5·0) | −47·6% (−60·4 to −29·6)* | ||
| Ebola virus disease | 0·0 (0·0 to 0·0) | −98·2% (−98·4 to −98·0)* | 0·0 (0·0 to 0·0) | −98·4% (−98·6 to −98·2)* | 0·5 (0·5 to 0·5) | −98·1% (−98·3 to −97·9)* | 0·0 (0·0 to 0·0) | −98·2% (−98·4 to −98·0)* | ||
| Zika virus disease | 0·0 (0·0 to 0·1) | .. | 0·0 (0·0 to 0·0) | .. | 1·0 (0·2 to 3·4) | .. | 0·0 (0·0 to 0·0) | .. | ||
| Other neglected tropical diseases | 12·6 (8·0 to 36·3) | 8·1% (−8·1 to 28·2) | 0·2 (0·1 to 0·5) | −3·7% (−18·3 to 13·9) | 804·3 (442·8 to 2696·6) | 3·9% (−16·3 to 29·4) | 11·6 (6·3 to 39·6) | −3·5% (−22·2 to 20·7) | ||
| Other infectious diseases | 830·5 (732·2 to 947·8) | −25·9% (−32·4 to −18·8)* | 11·6 (10·1 to 13·3) | −33·8% (−39·3 to −27·4)* | 53 008·6 (44 786·0 to 63 000·4) | −33·0% (−39·6 to −25·1)* | 762·8 (640·5 to 911·5) | −37·9% (−44·0 to −30·5)* | ||
| Meningitis | 288·0 (254·3 to 333·2) | −20·1% (−26·0 to −11·0)* | 4·0 (3·6 to 4·6) | −27·8% (−33·1 to −19·3)* | 19 436·9 (16 935·1 to 22 335·8) | −25·2% (−31·5 to −15·7)* | 280·5 (243·6 to 323·2) | −30·2% (−36·3 to −21·4)* | ||
| Pneumococcal meningitis | 42·1 (36·6 to 49·4) | −13·4% (−20·6 to −2·3)* | 0·6 (0·5 to 0·7) | −22·4% (−28·9 to −12·4)* | 2751·8 (2325·8 to 3276·5) | −18·5% (−26·8 to −6·5)* | 39·6 (33·4 to 47·0) | −24·2% (−32·1 to −12·8)* | ||
| H influenzae type B meningitis | 75·7 (66·7 to 92·0) | −33·7% (−39·6 to −26·0)* | 1·1 (0·9 to 1·3) | −40·6% (−45·8 to −33·9)* | 4907·3 (4232·2 to 5813·6) | −40·4% (−46·1 to −33·0)* | 70·5 (60·6 to 83·9) | −44·7% (−50·1 to −37·7)* | ||
| Meningococcal infection | 30·0 (25·7 to 35·7) | −31·5% (−37·4 to −22·8)* | 0·4 (0·4 to 0·5) | −37·1% (−42·6 to −29·2)* | 2180·3 (1819·8 to 2614·5) | −34·9% (−41·4 to −26·4)* | 31·9 (26·5 to 38·4) | −38·8% (−45·0 to −30·5)* | ||
| Other meningitis | 140·3 (121·4 to 161·8) | −8·9% (−15·4 to 1·4) | 2·0 (1·7 to 2·3) | −17·3% (−23·4 to −7·5)* | 9597·5 (8195·6 to 11 118·5) | −12·8% (−20·4 to −0·7)* | 138·5 (118·3 to 160·5) | −18·4% (−25·7 to −7·4)* | ||
| Encephalitis | 92·4 (83·1 to 107·9) | 0·0% (−14·2 to 16·2) | 1·2 (1·1 to 1·4) | −14·3% (−26·5 to −0·9)* | 4588·2 (4059·5 to 5230·7) | −12·1% (−28·1 to 4·5) | 64·1 (56·6 to 72·4) | −20·1% (−35·0 to −5·0)* | ||
| Diphtheria | 3·6 (2·2 to 6·1) | −23·9% (−55·6 to 36·4) | 0·1 (0·0 to 0·1) | −28·6% (−58·8 to 29·2) | 298·7 (181·8 to 510·0) | −23·9% (−56·7 to 38·7) | 4·4 (2·7 to 7·6) | −28·3% (−59·5 to 31·4) | ||
| Whooping cough | 91·8 (45·9 to 163·2) | −23·3% (−54·8 to 35·6) | 1·4 (0·7 to 2·4) | −27·1% (−57·1 to 28·8) | 7879·2 (3938·1 to 14 010·3) | −23·3% (−54·8 to 35·4) | 117·9 (58·9 to 209·6) | −27·1% (−57·0 to 28·8) | ||
| Tetanus | 38·1 (25·9 to 48·8) | −54·9% (−65·9 to −39·1)* | 0·5 (0·4 to 0·7) | −59·6% (−69·3 to −45·0)* | 2447·7 (1734·9 to 3199·0) | −59·3% (−69·9 to −43·5)* | 35·1 (25·0 to 46·3) | −62·1% (−72·1 to −47·0)* | ||
| Measles | 95·3 (34·5 to 205·2) | −57·0% (−61·9 to −51·9)* | 1·4 (0·5 to 3·1) | −59·3% (−64·0 to −54·4)* | 8105·1 (2935·7 to 17 469·0) | −56·9% (−61·8 to −51·8)* | 120·8 (43·7 to 260·4) | −59·2% (−63·9 to −54·3)* | ||
| Varicella and herpes zoster | 15·6 (14·4 to 17·3) | −16·4% (−22·9 to −9·5)* | 0·2 (0·2 to 0·2) | −29·2% (−34·7 to −23·4)* | 833·0 (742·3 to 938·1) | −22·5% (−31·4 to −13·2)* | 12·1 (10·7 to 13·6) | −28·4% (−36·6 to −19·4)* | ||
| Acute hepatitis | 126·4 (94·5 to 143·7) | −9·8% (−15·5 to −2·3)* | 1·6 (1·2 to 1·9) | −24·5% (−29·2 to −18·4)* | 5478·4 (4040·3 to 6330·0) | −21·7% (−27·7 to −14·4)* | 72·3 (52·9 to 83·9) | −31·2% (−36·5 to −24·9)* | ||
| Acute hepatitis A | 18·6 (13·6 to 23·8) | −33·1% (−41·9 to −22·5)* | 0·3 (0·2 to 0·3) | −38·7% (−46·8 to −28·6)* | 1286·7 (935·2 to 1633·7) | −36·0% (−45·1 to −24·3)* | 18·0 (13·0 to 22·9) | −40·7% (−49·1 to −29·0)* | ||
| Acute hepatitis B | 89·6 (66·1 to 102·5) | −0·8% (−8·4 to 8·5) | 1·1 (0·8 to 1·3) | −19·6% (−25·4 to −12·4)* | 3262·4 (2367·8 to 3819·1) | −12·2% (−19·7 to −2·7)* | 41·8 (30·1 to 49·3) | −25·6% (−31·9 to −17·5)* | ||
| Acute hepatitis C | 3·5 (1·9 to 6·0) | −23·7% (−35·9 to −9·4)* | 0·0 (0·0 to 0·1) | −32·1% (−42·4 to −19·6)* | 219·7 (120·1 to 371·3) | −31·0% (−43·3 to −15·3)* | 3·2 (1·8 to 5·4) | −35·5% (−47·2 to −20·7)* | ||
| Acute hepatitis E | 14·7 (10·4 to 18·5) | −15·8% (−27·2 to −3·1)* | 0·2 (0·1 to 0·2) | −25·8% (−35·3 to −15·6)* | 709·6 (489·6 to 903·9) | −25·5% (−35·2 to −14·5)* | 9·3 (6·4 to 11·8) | −31·9% (−40·6 to −22·0)* | ||
| Other unspecified infectious diseases | 79·3 (59·9 to 85·1) | 1·6% (−3·1 to 7·9) | 1·1 (0·8 to 1·2) | −13·4% (−17·5 to −8·1)* | 3941·3 (2831·7 to 4325·8) | −10·2% (−16·2 to −2·4)* | 55·6 (39·6 to 61·3) | −17·9% (−23·6 to −10·6)* | ||
| Maternal and neonatal disorders | 1977·4 (1890·1 to 2060·6) | −24·1% (−26·9 to −21·0)* | 29·5 (28·2 to 30·8) | −26·6% (−29·3 to −23·5)* | 167 684·6 (160 060·7 to 174 918·2) | −24·2% (−27·1 to −20·9)* | 2518·2 (2403·8 to 2627·1) | −26·5% (−29·3 to −23·3)* | ||
| Maternal disorders | 193·6 (179·9 to 209·6) | −24·0% (−28·4 to −19·5)* | 2·5 (2·3 to 2·7) | −30·7% (−34·8 to −26·6)* | 10 993·1 (10 198·9 to 11 928·5) | −25·3% (−29·7 to −20·9)* | 140·9 (130·8 to 153·0) | −31·5% (−35·5 to −27·5)* | ||
| Maternal haemorrhage | 38·5 (33·2 to 45·2) | −52·1% (−59·0 to −44·2)* | 0·5 (0·4 to 0·6) | −56·4% (−62·7 to −49·3)* | 2173·8 (1859·7 to 2552·5) | −53·0% (−60·1 to −45·0)* | 27·8 (23·8 to 32·7) | −57·1% (−63·6 to −49·7)* | ||
| Maternal sepsis and other pregnancy-related infections | 21·2 (18·2 to 25·0) | −27·1% (−38·8 to −15·1)* | 0·3 (0·2 to 0·3) | −33·5% (−44·2 to −22·6)* | 1198·0 (1022·8 to 1420·8) | −28·9% (−41·1 to −16·2)* | 15·4 (13·1 to 18·3) | −34·5% (−45·4 to −22·5)* | ||
| Maternal hypertensive disorders | 29·4 (25·4 to 34·5) | −5·5% (−20·7 to 11·2) | 0·4 (0·3 to 0·4) | −13·0% (−27·3 to 2·6) | 1729·6 (1487·6 to 2033·2) | −6·6% (−22·1 to 10·2) | 22·3 (19·2 to 26·4) | −13·6% (−28·1 to 2·0) | ||
| Maternal obstructed labour and uterine rupture | 13·0 (10·2 to 16·8) | −17·7% (−35·9 to 2·9) | 0·2 (0·1 to 0·2) | −25·2% (−41·0 to −6·3)* | 720·9 (565·5 to 946·4) | −18·9% (−37·6 to 1·9) | 9·2 (7·2 to 12·1) | −25·8% (−42·9 to −6·9)* | ||
| Maternal abortive outcome | 17·4 (14·7 to 20·8) | −7·0% (−22·3 to 10·1) | 0·2 (0·2 to 0·3) | −15·7% (−29·3 to −0·4)* | 963·4 (807·6 to 1161·1) | −8·9% (−24·2 to 8·7) | 12·3 (10·3 to 14·9) | −16·8% (−30·7 to −0·5)* | ||
| Ectopic pregnancy | 10·2 (7·1 to 15·2) | −11·6% (−41·4 to 27·9) | 0·1 (0·1 to 0·2) | −19·2% (−46·2 to 16·8) | 590·6 (409·0 to 881·4) | −13·3% (−43·8 to 26·9) | 7·6 (5·3 to 11·4) | −20·3% (−48·1 to 17·0) | ||
| Indirect maternal deaths | 34·1 (30·0 to 38·7) | −4·1% (−16·7 to 8·5) | 0·4 (0·4 to 0·5) | −12·5% (−24·0 to −1·0)* | 1934·4 (1694·2 to 2216·7) | −6·1% (−19·2 to 6·8) | 24·8 (21·7 to 28·5) | −13·9% (−25·8 to −2·3)* | ||
| Late maternal deaths | 3·4 (2·6 to 4·3) | −0·9% (−7·0 to 5·5) | 0·0 (0·0 to 0·1) | −9·5% (−14·7 to −4·0)* | 194·7 (152·2 to 251·4) | −2·0% (−8·2 to 4·1) | 2·5 (2·0 to 3·2) | −10·1% (−15·4 to −4·5)* | ||
| Maternal deaths aggravated by HIV/AIDS | 1·6 (1·0 to 2·1) | −23·9% (−31·0 to −16·0)* | 0·0 (0·0 to 0·0) | −32·1% (−38·4 to −25·2)* | 84·4 (53·0 to 113·8) | −26·7% (−33·6 to −19·2)* | 1·1 (0·7 to 1·4) | −34·2% (−40·6 to −27·5)* | ||
| Other maternal disorders | 24·8 (20·8 to 29·8) | −8·5% (−24·7 to 11·2) | 0·3 (0·3 to 0·4) | −16·5% (−31·2 to 1·5) | 1403·1 (1159·5 to 1690·3) | −9·8% (−26·7 to 10·8) | 18·0 (14·9 to 21·7) | −17·2% (−32·9 to 1·2) | ||
| Neonatal disorders | 1783·8 (1698·5 to 1864·7) | −24·1% (−27·2 to −20·6)* | 27·1 (25·8 to 28·3) | −26·2% (−29·1 to −22·7)* | 156 691·6 (149 207·2 to 163 802·2) | −24·1% (−27·2 to −20·6)* | 2377·2 (2263·7 to 2485·1) | −26·2% (−29·1 to −22·7)* | ||
| Neonatal preterm birth | 649·4 (605·4 to 721·3) | −26·2% (−31·3 to −21·5)* | 9·9 (9·2 to 10·9) | −28·1% (−33·2 to −23·6)* | 57 052·0 (53 182·3 to 63 367·1) | −26·2% (−31·3 to −21·5)* | 865·6 (806·9 to 961·5) | −28·1% (−33·2 to −23·6)* | ||
| Neonatal encephalopathy due to birth asphyxia and trauma | 533·3 (476·9 to 580·3) | −24·5% (−30·2 to −18·0)* | 8·1 (7·2 to 8·8) | −26·5% (−32·0 to −20·2)* | 46 845·9 (41 894·1 to 50 985·7) | −24·5% (−30·2 to −18·0)* | 710·8 (635·7 to 773·7) | −26·5% (−32·0 to −20·2)* | ||
| Neonatal sepsis and other neonatal infections | 203·0 (178·7 to 267·1) | −11·9% (−20·5 to −1·7)* | 3·1 (2·7 to 4·1) | −14·4% (−22·7 to −4·4)* | 17 830·7 (15 692·9 to 23 459·0) | −11·9% (−20·5 to −1·7)* | 270·4 (238·0 to 355·8) | −14·4% (−22·7 to −4·4)* | ||
| Haemolytic disease and other neonatal jaundice | 49·1 (42·9 to 55·9) | −37·5% (−45·3 to −28·2)* | 0·7 (0·7 to 0·8) | −39·3% (−46·8 to −30·2)* | 4309·1 (3771·2 to 4914·0) | −37·5% (−45·3 to −28·2)* | 65·4 (57·2 to 74·5) | −39·3% (−46·8 to −30·2)* | ||
| Other neonatal disorders | 349·0 (294·9 to 382·3) | −23·6% (−29·8 to −15·5)* | 5·3 (4·5 to 5·8) | −25·7% (−31·7 to −17·8)* | 30 654·0 (25 899·7 to 33 578·7) | −23·6% (−29·8 to −15·5)* | 465·0 (392·9 to 509·4) | −25·7% (−31·7 to −17·8)* | ||
| Nutritional deficiencies | 270·0 (249·3 to 295·5) | −23·9% (−29·2 to −15·7)* | 3·8 (3·5 to 4·2) | −33·6% (−38·1 to −26·5)* | 15 658·0 (14 051·5 to 17 506·6) | −34·7% (−40·5 to −26·1)* | 228·7 (204·9 to 255·9) | −39·4% (−44·8 to −31·4)* | ||
| Protein-energy malnutrition | 231·8 (212·4 to 254·2) | −26·1% (−31·7 to −17·9)* | 3·3 (3·0 to 3·7) | −34·6% (−39·4 to −27·5)* | 14 405·4 (12 873·5 to 16 128·0) | −35·1% (−41·1 to −26·7)* | 211·8 (189·0 to 237·3) | −39·4% (−45·0 to −31·6)* | ||
| Other nutritional deficiencies | 38·2 (33·7 to 44·6) | −7·2% (−14·6 to 3·1) | 0·5 (0·4 to 0·6) | −25·8% (−31·7 to −17·5)* | 1252·7 (1087·5 to 1435·2) | −29·2% (−36·9 to −19·7)* | 16·9 (14·6 to 19·5) | −38·6% (−45·4 to −30·4)* | ||
| Non-communicable diseases | 41 071·1 (40 470·9 to 41 548·9) | 22·7% (21·5 to 23·9)* | 536·1 (528·4 to 542·2) | −7·9% (−8·8 to −7·0)* | 872 601·8 (859 538·6 to 884 787·7) | 13·6% (12·2 to 14·9)* | 11 097·4 (10 928·6 to 11 253·8) | −9·6% (−10·7 to −8·6)* | ||
| Neoplasms | 9556·2 (9395·7 to 9692·3) | 25·4% (23·9 to 27·0)* | 121·2 (119·1 to 122·9) | −4·4% (−5·6 to −3·3)* | 225 738·1 (221 608·8 to 229 322·4) | 19·6% (17·8 to 21·4)* | 2803·4 (2751·5 to 2848·8) | −5·6% (−7·0 to −4·1)* | ||
| Lip and oral cavity cancer | 193·7 (184·7 to 201·6) | 35·6% (29·5 to 40·8)* | 2·4 (2·3 to 2·5) | 4·0% (−0·6 to 8·0) | 5090·6 (4819·5 to 5328·3) | 30·5% (23·8 to 36·4)* | 62·2 (58·9 to 65·1) | 3·0% (−2·3 to 7·6) | ||
| Nasopharynx cancer | 69·5 (66·9 to 72·3) | 24·4% (20·0 to 28·8)* | 0·9 (0·8 to 0·9) | −3·0% (−6·4 to 0·4) | 2034·5 (1954·7 to 2117·4) | 18·3% (13·9 to 23·1)* | 24·8 (23·8 to 25·8) | −5·0% (−8·5 to −1·3)* | ||
| Other pharynx cancer | 117·4 (102·1 to 124·5) | 40·4% (29·7 to 48·4)* | 1·4 (1·3 to 1·5) | 7·9% (−0·3 to 14·0) | 3204·2 (2766·3 to 3405·1) | 36·0% (25·4 to 44·2)* | 38·9 (33·5 to 41·3) | 6·5% (−1·7 to 12·8) | ||
| Oesophageal cancer | 436·0 (425·0 to 447·6) | 13·0% (9·9 to 16·3)* | 5·5 (5·3 to 5·6) | −14·5% (−16·9 to −12·0)* | 9647·5 (9410·7 to 9903·5) | 8·9% (5·8 to 12·2)* | 118·3 (115·4 to 121·4) | −16·2% (−18·6 to −13·7)* | ||
| Stomach cancer | 865·0 (848·3 to 884·7) | 9·4% (7·1 to 12·1)* | 11·0 (10·8 to 11·2) | −17·1% (−18·8 to −15·1)* | 18 782·0 (18 409·7 to 19 207·7) | 4·8% (2·4 to 7·4)* | 231·6 (227·0 to 236·8) | −18·6% (−20·5 to −16·6)* | ||
| Colon and rectum cancer | 896·0 (876·3 to 915·7) | 27·8% (24·0 to 31·3)* | 11·5 (11·3 to 11·8) | −4·3% (−7·1 to −1·8)* | 18 106·7 (17 678·0 to 18 525·0) | 23·8% (19·2 to 27·6)* | 224·7 (219·4 to 229·9) | −4·5% (−8·0 to −1·7)* | ||
| Liver cancer | 819·4 (789·7 to 855·5) | 27·0% (23·0 to 32·9)* | 10·2 (9·8 to 10·7) | −2·5% (−5·6 to 2·0) | 20 536·2 (19 678·7 to 21 551·9) | 21·2% (17·0 to 27·4)* | 250·7 (240·4 to 263·0) | −4·6% (−8·0 to 0·1) | ||
| Liver cancer due to hepatitis B | 325·4 (304·6 to 348·2) | 20·3% (15·3 to 28·2)* | 4·0 (3·7 to 4·3) | −6·2% (−10·0 to 0·1) | 9449·0 (8837·3 to 10 138·6) | 14·7% (9·7 to 21·9)* | 114·6 (107·3 to 123·0) | −8·4% (−12·2 to −2·6)* | ||
| Liver cancer due to hepatitis C | 234·3 (219·4 to 250·6) | 30·4% (26·7 to 35·0)* | 3·0 (2·8 to 3·2) | −2·1% (−4·9 to 1·4) | 4898·4 (4554·0 to 5259·3) | 26·9% (23·3 to 31·6)* | 60·3 (56·2 to 64·7) | −3·0% (−5·8 to 0·5) | ||
| Liver cancer due to alcohol use | 129·3 (114·5 to 147·3) | 31·7% (26·8 to 37·3)* | 1·6 (1·4 to 1·8) | 0·6% (−3·0 to 4·8) | 3040·7 (2647·6 to 3549·8) | 27·8% (22·4 to 33·9)* | 37·2 (32·5 to 43·3) | −0·6% (−4·5 to 3·9) | ||
| Liver cancer due to NASH | 66·9 (59·6 to 74·5) | 42·3% (38·0 to 47·6)* | 0·8 (0·8 to 0·9) | 7·6% (4·4 to 11·7)* | 1443·8 (1288·9 to 1605·9) | 37·3% (32·7 to 42·8)* | 17·8 (15·9 to 19·7) | 6·3% (2·9 to 10·5)* | ||
| Liver cancer due to other causes | 63·5 (57·4 to 70·6) | 28·2% (23·6 to 34·3)* | 0·8 (0·7 to 0·9) | −0·9% (−4·2 to 3·6) | 1704·2 (1528·4 to 1903·8) | 21·1% (16·0 to 27·4)* | 20·9 (18·8 to 23·3) | −3·5% (−7·2 to 1·4) | ||
| Gallbladder and biliary tract cancer | 174·0 (154·2 to 184·9) | 25·0% (21·5 to 28·7)* | 2·2 (2·0 to 2·4) | −6·7% (−9·4 to −4·0)* | 3434·0 (3009·7 to 3660·0) | 21·8% (17·8 to 26·3)* | 42·6 (37·3 to 45·4) | −6·8% (−9·9 to −3·5)* | ||
| Pancreatic cancer | 441·1 (432·8 to 449·0) | 39·9% (36·7 to 42·6)* | 5·6 (5·5 to 5·7) | 4·8% (2·5 to 6·8)* | 8988·1 (8806·6 to 9162·9) | 35·8% (32·5 to 38·6)* | 111·1 (108·9 to 113·2) | 4·0% (1·5 to 6·1)* | ||
| Larynx cancer | 126·5 (123·4 to 129·9) | 21·1% (17·8 to 24·4)* | 1·6 (1·5 to 1·6) | −7·7% (−10·1 to −5·2)* | 3170·0 (3089·7 to 3260·3) | 17·3% (13·9 to 20·9)* | 38·5 (37·6 to 39·6) | −9·1% (−11·7 to −6·4)* | ||
| Tracheal, bronchus, and lung cancer | 1883·1 (1844·2 to 1922·8) | 29·6% (26·5 to 32·5)* | 23·7 (23·3 to 24·2) | −2·0% (−4·3 to 0·1) | 40 391·6 (39 506·7 to 41 285·6) | 24·8% (21·7 to 27·6)* | 496·4 (485·5 to 507·2) | −4·1% (−6·5 to −2·0)* | ||
| Malignant skin melanoma | 61·7 (47·9 to 70·3) | 23·6% (19·0 to 26·9)* | 0·8 (0·6 to 0·9) | −5·1% (−8·5 to −2·5)* | 1513·2 (1220·7 to 1774·4) | 16·1% (12·7 to 20·0)* | 18·7 (15·1 to 21·9) | −7·2% (−9·8 to −3·8)* | ||
| Non-melanoma skin cancer | 65·1 (63·1 to 66·5) | 38·6% (34·9 to 41·2)* | 0·8 (0·8 to 0·9) | 2·7% (0·0 to 4·5)* | 1239·1 (1200·2 to 1266·6) | 30·0% (26·2 to 32·7)* | 15·5 (15·0 to 15·8) | 0·5% (−2·3 to 2·6) | ||
| Non-melanoma skin cancer (squamous-cell carcinoma) | 65·1 (63·1 to 66·5) | 38·6% (34·9 to 41·2)* | 0·8 (0·8 to 0·9) | 2·7% (0·0 to 4·5)* | 1239·1 (1200·2 to 1266·6) | 30·0% (26·2 to 32·7)* | 15·5 (15·0 to 15·8) | 0·5% (−2·3 to 2·6) | ||
| Breast cancer | 611·6 (589·2 to 640·7) | 27·0% (21·3 to 31·2)* | 7·6 (7·4 to 8·0) | −2·6% (−6·9 to 0·4) | 16 400·7 (15 737·0 to 17 320·2) | 23·9% (17·3 to 28·7)* | 200·2 (192·1 to 211·4) | −1·7% (−6·8 to 2·1) | ||
| Cervical cancer | 259·7 (241·1 to 269·2) | 18·8% (12·9 to 22·8)* | 3·2 (3·0 to 3·3) | −7·2% (−11·7 to −4·0)* | 7773·5 (7227·4 to 8087·8) | 15·1% (9·4 to 19·1)* | 94·6 (88·1 to 98·5) | −7·2% (−11·8 to −3·9)* | ||
| Uterine cancer | 85·2 (83·2 to 87·4) | 18·8% (15·8 to 22·5)* | 1·1 (1·0 to 1·1) | −10·4% (−12·5 to −7·7)* | 1930·0 (1879·9 to 1983·0) | 14·8% (11·6 to 19·0)* | 23·7 (23·1 to 24·3) | −11·2% (−13·7 to −8·0)* | ||
| Ovarian cancer | 176·0 (171·4 to 181·2) | 30·3% (26·8 to 33·7)* | 2·2 (2·1 to 2·3) | −1·0% (−3·6 to 1·6) | 4496·9 (4370·7 to 4642·1) | 29·1% (24·8 to 33·1)* | 54·9 (53·4 to 56·7) | 1·1% (−2·2 to 4·2) | ||
| Prostate cancer | 415·9 (357·3 to 489·5) | 32·5% (29·3 to 38·4)* | 5·5 (4·7 to 6·5) | −2·5% (−4·9 to 1·9) | 6214·5 (5324·2 to 7293·0) | 28·3% (24·9 to 34·5)* | 79·3 (68·1 to 93·0) | −3·6% (−6·2 to 1·2) | ||
| Testicular cancer | 7·7 (7·4 to 8·0) | 6·1% (2·3 to 10·9)* | 0·1 (0·1 to 0·1) | −9·4% (−12·6 to −5·2)* | 338·7 (323·8 to 357·4) | 0·9% (−3·3 to 6·3) | 4·3 (4·1 to 4·5) | −10·8% (−14·5 to −6·1)* | ||
| Kidney cancer | 138·5 (128·7 to 142·5) | 30·1% (26·2 to 34·1)* | 1·8 (1·6 to 1·8) | −1·3% (−4·3 to 1·7) | 3143·3 (2952·2 to 3234·1) | 23·1% (18·5 to 27·3)* | 39·4 (37·0 to 40·5) | −3·3% (−6·9 to 0·0) | ||
| Bladder cancer | 196·5 (191·5 to 205·8) | 27·8% (25·1 to 30·4)* | 2·6 (2·5 to 2·7) | −5·4% (−7·3 to −3·4)* | 3350·1 (3257·4 to 3511·6) | 22·6% (19·9 to 25·3)* | 42·2 (41·0 to 44·1) | −6·9% (−8·9 to −4·8)* | ||
| Brain and nervous system cancer | 247·1 (213·0 to 265·0) | 29·2% (23·2 to 33·4)* | 3·1 (2·7 to 3·3) | 3·8% (−1·0 to 7·0) | 8577·8 (7527·0 to 9359·3) | 18·4% (11·9 to 24·6)* | 109·8 (96·1 to 120·0) | 0·0% (−5·6 to 5·3) | ||
| Thyroid cancer | 41·2 (39·9 to 44·1) | 28·9% (24·3 to 33·3)* | 0·5 (0·5 to 0·6) | −1·2% (−4·5 to 2·0) | 1001·2 (963·6 to 1074·0) | 22·1% (16·7 to 28·0)* | 12·4 (12·0 to 13·4) | −2·3% (−6·6 to 2·4) | ||
| Mesothelioma | 29·9 (29·1 to 30·6) | 26·9% (20·1 to 32·6)* | 0·4 (0·4 to 0·4) | −3·4% (−8·4 to 0·7) | 655·7 (635·2 to 677·0) | 21·0% (13·8 to 27·3)* | 8·1 (7·9 to 8·4) | −5·4% (−10·8 to −0·8)* | ||
| Hodgkin lymphoma | 32·6 (27·6 to 38·1) | 0·2% (−3·5 to 3·6) | 0·4 (0·4 to 0·5) | −16·8% (−19·8 to −14·0)* | 1327·6 (1110·1 to 1567·7) | −5·2% (−8·6 to −1·8)* | 17·1 (14·3 to 20·2) | −17·1% (−20·1 to −13·9)* | ||
| Non-Hodgkin lymphoma | 248·6 (243·5 to 253·1) | 29·4% (25·5 to 32·4)* | 3·2 (3·1 to 3·2) | 0·1% (−2·7 to 2·4) | 6828·8 (6611·8 to 7020·0) | 22·1% (15·6 to 26·9)* | 86·8 (84·0 to 89·5) | 0·2% (−5·2 to 4·3) | ||
| Multiple myeloma | 107·1 (98·5 to 118·9) | 32·7% (28·4 to 36·4)* | 1·4 (1·3 to 1·5) | −0·4% (−3·5 to 2·4) | 2234·7 (2091·4 to 2493·2) | 30·4% (25·6 to 34·4)* | 27·7 (25·9 to 30·8) | 0·3% (−3·3 to 3·4) | ||
| Leukaemia | 347·6 (317·3 to 364·9) | 12·8% (9·5 to 15·6)* | 4·5 (4·1 to 4·7) | −9·6% (−12·2 to −7·4)* | 11 712·0 (10 531·4 to 12 523·3) | 2·3% (−3·7 to 6·2) | 153·4 (137·9 to 164·5) | −12·0% (−17·3 to −8·5)* | ||
| Acute lymphoid leukaemia | 52·2 (46·0 to 56·7) | 14·1% (2·6 to 23·2)* | 0·7 (0·6 to 0·7) | −1·5% (−11·6 to 6·2) | 2661·7 (2341·7 to 2941·1) | 5·3% (−8·6 to 15·4) | 36·1 (31·7 to 40·0) | −4·7% (−17·6 to 4·7) | ||
| Chronic lymphoid leukaemia | 35·2 (33·5 to 36·9) | 21·4% (17·7 to 25·0)* | 0·5 (0·4 to 0·5) | −10·3% (−13·0 to −7·6)* | 634·1 (595·7 to 674·2) | 18·3% (14·2 to 22·4)* | 8·0 (7·5 to 8·5) | −9·2% (−12·3 to −6·1)* | ||
| Acute myeloid leukaemia | 99·9 (91·3 to 104·6) | 24·6% (17·1 to 29·8)* | 1·3 (1·2 to 1·3) | −1·0% (−6·6 to 3·0) | 3192·6 (2868·8 to 3405·6) | 16·2% (4·4 to 24·6)* | 41·3 (37·0 to 44·1) | −1·4% (−11·3 to 5·8) | ||
| Chronic myeloid leukaemia | 24·1 (22·2 to 26·1) | 3·3% (0·4 to 6·4)* | 0·3 (0·3 to 0·3) | −19·9% (−22·2 to −17·6)* | 643·3 (583·4 to 699·1) | −1·7% (−5·2 to 1·5) | 8·0 (7·3 to 8·7) | −19·7% (−22·4 to −17·1)* | ||
| Other leukaemia | 136·2 (121·0 to 146·8) | 4·9% (0·9 to 9·7)* | 1·8 (1·6 to 1·9) | −15·6% (−18·7 to −12·1)* | 4580·2 (3955·1 to 5013·3) | −8·1% (−14·6 to −1·8)* | 60·0 (51·9 to 65·7) | −20·8% (−26·5 to −15·4)* | ||
| Other malignant cancers | 359·5 (331·4 to 370·8) | 26·8% (23·3 to 29·5)* | 4·6 (4·2 to 4·8) | 0·1% (−2·6 to 2·2) | 11 189·0 (10 386·5 to 11 664·8) | 18·4% (12·8 to 22·8)* | 144·4 (133·8 to 150·9) | −0·3% (−5·1 to 3·5) | ||
| Other neoplasms | 102·9 (80·2 to 122·4) | 42·0% (35·6 to 51·7)* | 1·3 (1·0 to 1·6) | 7·4% (2·1 to 15·8)* | 2425·8 (2024·4 to 2932·1) | 32·9% (25·9 to 42·7)* | 31·1 (25·9 to 37·4) | 7·9% (2·0 to 16·5)* | ||
| Myelodysplastic, myeloproliferative, and other haemopoietic neoplasms | 98·8 (76·7 to 118·1) | 42·6% (36·2 to 52·2)* | 1·3 (1·0 to 1·5) | 7·1% (1·8 to 15·3)* | 2189·1 (1820·8 to 2665·5) | 33·9% (26·6 to 43·3)* | 27·9 (23·2 to 33·8) | 7·2% (1·2 to 15·6)* | ||
| Other benign and in-situ neoplasms | 4·1 (3·2 to 4·8) | 29·6% (17·2 to 44·5)* | 0·1 (0·0 to 0·1) | 15·5% (4·1 to 29·2)* | 236·8 (186·4 to 277·7) | 25·0% (12·7 to 38·6)* | 3·2 (2·5 to 3·7) | 14·3% (3·0 to 27·0)* | ||
| Cardiovascular diseases | 17 790·9 (17 527·1 to 18 042·7) | 21·1% (19·7 to 22·6)* | 233·1 (229·7 to 236·4) | −10·3% (−11·4 to −9·3)* | 330 172·6 (324 899·3 to 335 159·9) | 14·7% (13·3 to 16·2)* | 4148·0 (4082·0 to 4210·8) | −11·3% (−12·4 to −10·1)* | ||
| Rheumatic heart disease | 285·5 (266·2 to 303·3) | 1·3% (−3·9 to 6·0) | 3·7 (3·4 to 3·9) | −21·3% (−25·2 to −17·8)* | 7492·6 (6926·7 to 8046·7) | −10·2% (−15·4 to −6·2)* | 94·5 (87·5 to 101·4) | −25·9% (−30·0 to −22·7)* | ||
| Ischaemic heart disease | 8930·4 (8790·7 to 9138·7) | 22·3% (20·6 to 23·8)* | 116·9 (115·1 to 119·7) | −9·7% (−11·0 to −8·7)* | 164 983·4 (162 168·9 to 168 584·2) | 17·3% (15·4 to 19·0)* | 2065·9 (2030·6 to 2111·7) | −9·8% (−11·2 to −8·5)* | ||
| Stroke | 6167·3 (6044·3 to 6327·6) | 16·6% (14·7 to 18·6)* | 80·5 (78·9 to 82·6) | −13·6% (−15·0 to −12·1)* | 113 355·9 (110 957·8 to 116 180·6) | 12·1% (9·9 to 14·1)* | 1422·2 (1392·0 to 1457·7) | −13·8% (−15·5 to −12·3)* | ||
| Ischaemic stroke | 2747·4 (2657·1 to 2857·6) | 21·2% (19·0 to 23·3)* | 36·6 (35·5 to 38·0) | −11·8% (−13·4 to −10·3)* | 40 834·1 (39 133·3 to 43 140·9) | 16·9% (14·3 to 19·3)* | 521·8 (500·5 to 550·2) | −12·0% (−13·9 to −10·3)* | ||
| Intracerebral haemorrhage | 2974·9 (2880·8 to 3072·8) | 12·5% (9·6 to 15·1)* | 38·2 (37·0 to 39·4) | −15·7% (−17·8 to −13·8)* | 61 562·6 (59 598·2 to 63 531·4) | 9·3% (6·5 to 11·8)* | 764·1 (739·7 to 788·4) | −15·4% (−17·6 to −13·5)* | ||
| Subarachnoid haemorrhage | 445·0 (417·2 to 492·3) | 18·4% (13·4 to 24·6)* | 5·7 (5·3 to 6·3) | −9·4% (−13·1 to −4·9)* | 10 959·3 (10 294·3 to 12 264·1) | 10·7% (6·8 to 16·5)* | 136·4 (128·2 to 152·5) | −11·4% (−14·5 to −7·0)* | ||
| Hypertensive heart disease | 925·7 (681·4 to 994·9) | 46·6% (26·3 to 59·3)* | 12·3 (9·0 to 13·2) | 7·5% (−7·3 to 16·3) | 15 135·2 (11 349·8 to 16 311·7) | 35·7% (19·1 to 47·9)* | 191·5 (143·3 to 206·2) | 3·8% (−8·8 to 12·9) | ||
| Non-rheumatic valvular heart disease | 144·9 (121·8 to 150·4) | 31·8% (27·7 to 34·7)* | 2·0 (1·6 to 2·0) | −5·3% (−7·9 to −3·2)* | 2168·4 (1980·3 to 2322·7) | 21·8% (18·6 to 25·0)* | 27·9 (25·4 to 29·6) | −6·2% (−8·5 to −3·8)* | ||
| Non-rheumatic calcific aortic valve disease | 102·7 (82·7 to 108·0) | 40·0% (33·0 to 44·9)* | 1·4 (1·1 to 1·5) | −1·0% (−5·6 to 2·2) | 1345·1 (1185·5 to 1432·5) | 30·4% (25·1 to 35·3)* | 17·5 (15·3 to 18·6) | −1·7% (−5·3 to 1·6) | ||
| Non-rheumatic degenerative mitral valve disease | 35·7 (30·5 to 42·5) | 16·4% (11·0 to 23·4)* | 0·5 (0·4 to 0·6) | −14·0% (−18·1 to −8·6)* | 683·6 (592·6 to 787·0) | 10·3% (4·9 to 16·2)* | 8·7 (7·5 to 10·0) | −13·0% (−16·9 to −8·3)* | ||
| Other non-rheumatic valve diseases | 6·4 (4·9 to 8·7) | 9·7% (−4·1 to 42·2) | 0·1 (0·1 to 0·1) | −17·8% (−28·5 to 8·0) | 139·7 (105·8 to 187·5) | 8·1% (−2·4 to 27·6) | 1·8 (1·4 to 2·4) | −12·4% (−21·3 to 4·7) | ||
| Cardiomyopathy and myocarditis | 368·5 (341·9 to 386·9) | 8·1% (3·8 to 18·2)* | 4·8 (4·5 to 5·0) | −16·6% (−19·8 to −9·4)* | 9623·3 (8867·5 to 10 208·8) | −5·1% (−9·6 to 5·5) | 122·4 (113·0 to 129·7) | −21·5% (−25·1 to −13·0)* | ||
| Myocarditis | 46·5 (39·7 to 51·8) | 14·4% (5·6 to 29·7)* | 0·6 (0·5 to 0·7) | −13·3% (−20·4 to −0·1)* | 1259·3 (1100·1 to 1415·5) | −0·3% (−6·9 to 7·6) | 16·6 (14·5 to 18·5) | −15·2% (−21·1 to −7·7)* | ||
| Alcoholic cardiomyopathy | 88·9 (80·9 to 96·3) | −25·3% (−29·5 to −8·3)* | 1·1 (1·0 to 1·2) | −40·5% (−43·7 to −27·6)* | 2849·2 (2599·0 to 3073·1) | −30·7% (−34·7 to −12·1)* | 34·7 (31·7 to 37·5) | −43·2% (−46·5 to −28·2)* | ||
| Other cardiomyopathy | 233·2 (213·7 to 248·3) | 28·5% (24·5 to 32·4)* | 3·1 (2·8 to 3·3) | −3·6% (−6·7 to −0·7)* | 5514·8 (4946·7 to 5992·9) | 15·7% (10·9 to 19·9)* | 71·1 (64·0 to 77·0) | −5·4% (−9·3 to −2·0)* | ||
| Atrial fibrillation and flutter | 287·2 (276·4 to 304·8) | 47·8% (45·4 to 50·6)* | 4·0 (3·9 to 4·2) | 2·6% (0·9 to 4·6)* | 3054·5 (2923·0 to 3235·4) | 40·5% (37·9 to 43·4)* | 40·6 (38·9 to 43·1) | 2·2% (0·3 to 4·2)* | ||
| Aortic aneurysm | 167·2 (159·8 to 174·1) | 23·7% (19·9 to 27·6)* | 2·2 (2·1 to 2·3) | −8·5% (−11·2 to −5·8)* | 3039·9 (2877·2 to 3186·4) | 19·0% (14·5 to 23·6)* | 38·2 (36·2 to 40·0) | −8·5% (−11·9 to −5·1)* | ||
| Peripheral vascular disease | 70·2 (43·2 to 123·3) | 55·7% (31·0 to 74·2)* | 1·0 (0·6 to 1·7) | 10·5% (−6·8 to 24·1) | 916·9 (576·9 to 1540·0) | 48·3% (25·0 to 65·6)* | 11·8 (7·4 to 20·0) | 9·7% (−7·5 to 22·6) | ||
| Endocarditis | 83·4 (74·3 to 94·3) | 32·2% (25·2 to 36·8)* | 1·1 (1·0 to 1·2) | 1·0% (−4·0 to 5·0) | 2174·5 (2033·2 to 2373·0) | 16·9% (8·9 to 22·2)* | 28·3 (26·4 to 30·9) | −2·3% (−8·8 to 2·1) | ||
| Other cardiovascular and circulatory diseases | 360·7 (338·1 to 392·9) | 21·9% (17·9 to 24·8)* | 4·7 (4·4 to 5·1) | −7·9% (−10·9 to −5·9)* | 8228·0 (7681·4 to 9061·9) | 12·6% (9·5 to 15·7)* | 104·7 (97·8 to 115·2) | −9·4% (−12·0 to −7·1)* | ||
| Chronic respiratory diseases | 3914·2 (3790·6 to 4044·8) | 15·8% (12·7 to 19·3)* | 51·4 (49·7 to 53·1) | −14·2% (−16·5 to −11·5)* | 68 004·9 (65 869·4 to 70 592·2) | 9·7% (7·0 to 13·2)* | 861·9 (835·4 to 895·0) | −15·7% (−17·7 to −13·0)* | ||
| Chronic obstructive pulmonary disease | 3197·8 (3029·0 to 3358·9) | 17·5% (13·3 to 21·1)* | 42·2 (40·0 to 44·2) | −13·6% (−16·5 to −11·0)* | 50 990·0 (47 678·7 to 54 146·9) | 13·2% (8·8 to 16·9)* | 647·3 (605·9 to 686·4) | −14·3% (−17·5 to −11·6)* | ||
| Pneumoconiosis | 21·6 (20·5 to 22·7) | 10·7% (5·1 to 16·6)* | 0·3 (0·3 to 0·3) | −16·7% (−20·8 to −12·4)* | 426·9 (403·6 to 452·9) | 7·9% (1·8 to 14·6)* | 5·3 (5·0 to 5·6) | −16·4% (−21·1 to −11·3)* | ||
| Silicosis | 11·3 (10·4 to 12·5) | 12·0% (1·2 to 22·8)* | 0·1 (0·1 to 0·2) | −15·5% (−23·6 to −7·4)* | 235·7 (210·3 to 258·2) | 11·8% (−0·7 to 23·6) | 2·9 (2·6 to 3·2) | −13·4% (−23·1 to −4·3)* | ||
| Asbestosis | 3·4 (2·3 to 3·9) | 23·3% (15·1 to 33·9)* | 0·0 (0·0 to 0·1) | −8·3% (−14·1 to −0·4)* | 54·6 (38·6 to 65·6) | 15·6% (7·4 to 28·5)* | 0·7 (0·5 to 0·8) | −11·4% (−17·5 to −1·3)* | ||
| Coal worker pneumoconiosis | 3·2 (2·9 to 4·0) | −2·2% (−12·0 to 11·7) | 0·0 (0·0 to 0·1) | −26·6% (−33·8 to −16·7)* | 58·9 (52·2 to 76·4) | −6·4% (−16·3 to 8·3) | 0·7 (0·7 to 1·0) | −27·9% (−35·4 to −16·9)* | ||
| Other pneumoconiosis | 3·6 (3·1 to 4·5) | 8·9% (0·0 to 25·4)* | 0·0 (0·0 to 0·1) | −17·5% (−24·1 to −5·0)* | 77·6 (66·1 to 96·4) | 4·2% (−3·8 to 19·5) | 1·0 (0·8 to 1·2) | −18·3% (−24·7 to −5·9)* | ||
| Asthma | 495·1 (338·2 to 641·2) | −0·7% (−6·2 to 8·1) | 6·3 (4·3 to 8·2) | −23·9% (−28·1 to −17·2)* | 12 139·9 (8538·5 to 15 576·3) | −7·5% (−11·4 to −1·6)* | 152·8 (108·3 to 195·8) | −25·8% (−28·9 to −20·4)* | ||
| Interstitial lung disease and pulmonary sarcoidosis | 147·6 (114·9 to 181·3) | 49·8% (39·0 to 58·6)* | 1·9 (1·5 to 2·4) | 11·4% (4·0 to 17·9)* | 2716·7 (2156·9 to 3371·3) | 43·0% (32·1 to 53·4)* | 34·2 (27·1 to 42·4) | 10·4% (2·3 to 18·6)* | ||
| Other chronic respiratory diseases | 52·1 (45·9 to 59·6) | 21·3% (14·1 to 34·2)* | 0·7 (0·6 to 0·8) | −3·2% (−8·7 to 6·7) | 1731·4 (1504·5 to 1998·9) | 10·8% (3·2 to 24·3)* | 22·1 (19·3 to 25·5) | −6·3% (−12·6 to 5·3) | ||
| Digestive diseases | 2377·7 (2295·1 to 2518·0) | 15·3% (12·1 to 19·7)* | 30·3 (29·2 to 32·1) | −10·7% (−13·1 to −7·3)* | 65 348·4 (62 343·9 to 69 371·3) | 7·5% (4·2 to 11·9)* | 819·8 (781·7 to 869·7) | −12·2% (−14·9 to −8·5)* | ||
| Cirrhosis and other chronic liver diseases | 1322·9 (1268·2 to 1449·1) | 15·0% (8·7 to 21·5)* | 16·5 (15·8 to 18·1) | −9·7% (−14·7 to −4·6)* | 39 652·4 (37 985·2 to 43 624·9) | 8·9% (3·4 to 14·4)* | 488·9 (468·0 to 537·5) | −11·3% (−15·8 to −6·9)* | ||
| Cirrhosis and other chronic liver diseases due to hepatitis B | 384·0 (349·1 to 441·7) | 8·6% (1·1 to 17·3)* | 4·8 (4·3 to 5·5) | −14·3% (−20·2 to −7·3)* | 11 721·5 (10 648·0 to 13 431·7) | 3·4% (−3·3 to 10·7) | 144·1 (130·8 to 165·3) | −15·5% (−20·9 to −9·5)* | ||
| Cirrhosis and other chronic liver diseases due to hepatitis C | 342·2 (312·6 to 381·1) | 17·4% (11·3 to 23·0)* | 4·2 (3·9 to 4·7) | −8·4% (−13·0 to −3·9)* | 9980·1 (9074·7 to 11 116·9) | 12·2% (6·8 to 17·3)* | 121·9 (111·0 to 135·8) | −9·6% (−13·9 to −5·5)* | ||
| Cirrhosis and other chronic liver diseases due to alcohol use | 332·3 (303·0 to 373·3) | 16·9% (11·2 to 23·7)* | 4·1 (3·7 to 4·6) | −8·8% (−13·2 to −3·4)* | 9785·4 (8919·3 to 10 962·1) | 12·3% (7·1 to 18·3)* | 119·0 (108·6 to 133·5) | −10·0% (−14·2 to −5·2)* | ||
| Cirrhosis due to NASH | 118·0 (108·6 to 128·6) | 27·6% (21·2 to 33·3)* | 1·5 (1·3 to 1·6) | −1·4% (−6·3 to 3·1) | 3285·5 (3011·9 to 3586·8) | 22·2% (16·6 to 27·2)* | 40·0 (36·6 to 43·6) | −3·0% (−7·4 to 1·0) | ||
| Cirrhosis and other chronic liver diseases due to other causes | 146·4 (130·9 to 164·6) | 14·2% (8·2 to 20·2)* | 1·9 (1·7 to 2·1) | −8·6% (−13·4 to −3·8)* | 4880·0 (4392·5 to 5457·1) | 2·1% (−4·3 to 10·7) | 63·9 (57·5 to 71·4) | −12·0% (−17·5 to −4·5)* | ||
| Upper digestive system diseases | 292·1 (279·7 to 312·3) | 2·9% (−1·3 to 8·6) | 3·8 (3·6 to 4·0) | −21·6% (−24·8 to −17·3)* | 6789·9 (6413·1 to 7259·0) | −4·5% (−9·5 to 1·8) | 85·2 (80·4 to 91·2) | −23·3% (−27·3 to −18·4)* | ||
| Peptic ulcer disease | 240·3 (229·4 to 258·8) | 0·6% (−3·6 to 5·6) | 3·1 (3·0 to 3·3) | −23·5% (−26·6 to −19·7)* | 5513·3 (5202·4 to 5947·8) | −6·8% (−11·4 to −1·5)* | 69·1 (65·1 to 74·7) | −25·4% (−29·0 to −21·0)* | ||
| Gastritis and duodenitis | 51·8 (43·0 to 56·9) | 15·5% (7·5 to 28·9)* | 0·7 (0·6 to 0·7) | −11·7% (−17·6 to −2·2)* | 1276·6 (1047·1 to 1419·7) | 6·8% (−3·1 to 22·4) | 16·1 (13·2 to 17·9) | −13·2% (−21·1 to −1·3)* | ||
| Appendicitis | 43·9 (40·2 to 47·5) | 1·8% (−4·0 to 9·6) | 0·6 (0·5 to 0·6) | −17·0% (−21·5 to −10·7)* | 1633·2 (1473·2 to 1772·7) | −8·7% (−16·7 to 0·6) | 21·4 (19·3 to 23·3) | −20·1% (−27·2 to −12·1)* | ||
| Paralytic ileus and intestinal obstruction | 240·5 (198·7 to 261·6) | 21·1% (14·4 to 29·0)* | 3·2 (2·7 to 3·5) | −5·8% (−11·0 to 0·3) | 7245·9 (5866·8 to 7980·6) | 6·5% (−3·1 to 15·5) | 97·0 (78·9 to 106·8) | −8·7% (−16·8 to −0·8)* | ||
| Inguinal, femoral, and abdominal hernia | 44·2 (38·6 to 50·0) | 21·7% (16·2 to 28·4)* | 0·6 (0·5 to 0·7) | −8·9% (−12·9 to −4·2)* | 914·3 (792·8 to 1021·9) | 12·1% (4·5 to 20·4)* | 11·7 (10·1 to 13·1) | −10·6% (−16·5 to −3·9)* | ||
| Inflammatory bowel disease | 38·6 (31·6 to 41·2) | 20·4% (11·5 to 27·2)* | 0·5 (0·4 to 0·5) | −10·5% (−16·0 to −5·9)* | 829·7 (711·4 to 900·7) | 10·3% (−2·7 to 19·5) | 10·7 (9·1 to 11·7) | −11·3% (−20·7 to −4·5)* | ||
| Vascular intestinal disorders | 96·1 (89·0 to 100·8) | 22·6% (17·0 to 28·1)* | 1·3 (1·2 to 1·3) | −10·2% (−14·2 to −6·2)* | 1570·1 (1433·3 to 1667·3) | 17·6% (10·7 to 24·8)* | 20·0 (18·3 to 21·3) | −10·0% (−15·3 to −5·0)* | ||
| Gallbladder and biliary diseases | 110·5 (105·5 to 116·6) | 28·8% (25·3 to 33·8)* | 1·5 (1·4 to 1·6) | −5·0% (−7·5 to −1·7)* | 1983·2 (1863·2 to 2092·0) | 18·5% (13·4 to 25·3)* | 25·4 (23·8 to 26·8) | −6·9% (−10·9 to −1·8)* | ||
| Pancreatitis | 101·6 (89·5 to 108·3) | 20·6% (16·4 to 25·7)* | 1·3 (1·1 to 1·4) | −5·7% (−9·0 to −1·7)* | 2890·0 (2537·1 to 3102·9) | 13·8% (8·7 to 19·5)* | 35·8 (31·4 to 38·4) | −6·8% (−10·9 to −2·1)* | ||
| Other digestive diseases | 87·3 (81·9 to 93·3) | 25·4% (18·1 to 32·3)* | 1·2 (1·1 to 1·2) | −7·1% (−12·1 to −2·4)* | 1839·7 (1663·9 to 2038·5) | 16·4% (5·8 to 27·4)* | 23·7 (21·5 to 26·3) | −6·5% (−14·9 to 1·8) | ||
| Neurological disorders | 3094·2 (3039·6 to 3142·6) | 42·1% (40·2 to 43·9)* | 43·1 (42·3 to 43·7) | 0·1% (−1·2 to 1·3) | 38 004·5 (37 134·8 to 39 174·6) | 26·2% (23·9 to 30·2)* | 507·6 (496·1 to 523·4) | −3·1% (−4·8 to −0·1)* | ||
| Alzheimer's disease and other dementias | 2514·6 (2470·5 to 2550·3) | 46·2% (43·9 to 48·0)* | 35·4 (34·8 to 35·9) | 0·6% (−0·9 to 1·8) | 23 951·1 (23 523·6 to 24 326·8) | 38·6% (35·7 to 40·9)* | 323·7 (317·9 to 328·7) | −0·3% (−2·3 to 1·2) | ||
| Parkinson's disease | 340·6 (324·4 to 355·1) | 38·3% (33·3 to 41·4)* | 4·6 (4·4 to 4·8) | 0·8% (−2·8 to 3·0) | 4361·2 (4182·8 to 4578·7) | 33·8% (28·5 to 37·0)* | 56·9 (54·5 to 59·8) | 0·3% (−3·6 to 2·6) | ||
| Epilepsy | 130·2 (117·0 to 150·8) | 3·8% (−1·6 to 15·7) | 1·7 (1·5 to 2·0) | −10·7% (−15·4 to −0·5)* | 6232·1 (5709·8 to 7289·7) | −5·5% (−11·6 to 8·3) | 82·6 (75·5 to 96·6) | −14·9% (−20·6 to −2·1)* | ||
| Multiple sclerosis | 20·7 (17·7 to 22·2) | 22·4% (8·0 to 27·8)* | 0·3 (0·2 to 0·3) | −3·9% (−14·5 to 0·4) | 628·2 (563·0 to 682·4) | 17·1% (4·1 to 24·5)* | 7·7 (6·9 to 8·3) | −5·5% (−15·1 to 0·6) | ||
| Motor neuron disease | 34·1 (32·8 to 37·1) | 32·7% (28·0 to 37·0)* | 0·4 (0·4 to 0·5) | 1·2% (−2·4 to 4·5) | 828·1 (796·7 to 917·1) | 27·2% (22·6 to 31·3)* | 10·3 (9·9 to 11·4) | 0·1% (−3·5 to 3·3) | ||
| Other neurological disorders | 53·9 (51·6 to 59·0) | 25·4% (17·8 to 32·3)* | 0·7 (0·7 to 0·8) | 2·0% (−3·9 to 6·8) | 2003·8 (1856·8 to 2269·5) | 11·4% (3·6 to 21·1)* | 26·5 (24·3 to 30·1) | −2·8% (−9·3 to 5·1) | ||
| Mental disorders | 0·3 (0·3 to 0·4) | 19·9% (10·0 to 29·2)* | 0·0 (0·0 to 0·0) | 7·5% (−1·4 to 15·9) | 17·5 (15·9 to 19·2) | 18·5% (8·8 to 27·5)* | 0·2 (0·2 to 0·2) | 7·2% (−1·6 to 15·3) | ||
| Eating disorders | 0·3 (0·3 to 0·4) | 19·9% (10·0 to 29·2)* | 0·0 (0·0 to 0·0) | 7·5% (−1·4 to 15·9) | 17·5 (15·9 to 19·2) | 18·5% (8·8 to 27·5)* | 0·2 (0·2 to 0·2) | 7·2% (−1·6 to 15·3) | ||
| Anorexia nervosa | 0·2 (0·2 to 0·3) | 17·6% (7·0 to 27·6)* | 0·0 (0·0 to 0·0) | 5·5% (−4·1 to 14·4) | 12·7 (10·9 to 14·1) | 15·9% (5·6 to 25·6)* | 0·2 (0·1 to 0·2) | 5·0% (−4·4 to 13·7) | ||
| Bulimia nervosa | 0·1 (0·1 to 0·1) | 26·4% (12·9 to 40·5)* | 0·0 (0·0 to 0·0) | 13·5% (1·0 to 26·2)* | 4·8 (4·0 to 6·7) | 25·9% (12·0 to 40·0)* | 0·1 (0·1 to 0·1) | 13·6% (1·1 to 26·3)* | ||
| Substance use disorders | 351·5 (334·1 to 362·7) | 23·8% (20·2 to 27·3)* | 4·3 (4·1 to 4·5) | 2·0% (−1·0 to 5·0) | 13 597·6 (12 979·5 to 14 033·3) | 18·8% (15·3 to 22·4)* | 168·0 (160·4 to 173·3) | 0·8% (−2·2 to 3·9) | ||
| Alcohol use disorders | 184·9 (166·7 to 193·0) | 2·7% (−2·2 to 7·7) | 2·3 (2·0 to 2·4) | −16·5% (−20·4 to −12·4)* | 6750·4 (6113·2 to 7082·7) | −2·1% (−7·2 to 3·3) | 82·4 (74·7 to 86·5) | −18·4% (−22·7 to −13·9)* | ||
| Drug use disorders | 166·6 (163·4 to 170·3) | 60·2% (56·9 to 63·6)* | 2·1 (2·0 to 2·1) | 34·1% (31·4 to 36·9)* | 6847·2 (6704·5 to 7004·4) | 50·4% (47·0 to 54·0)* | 85·5 (83·7 to 87·5) | 30·5% (27·6 to 33·5)* | ||
| Opioid use disorders | 109·5 (105·7 to 113·6) | 77·0% (68·8 to 88·5)* | 1·4 (1·3 to 1·4) | 49·4% (42·5 to 59·2)* | 4641·2 (4480·6 to 4818·9) | 65·0% (57·3 to 75·0)* | 58·0 (56·1 to 60·3) | 43·9% (37·1 to 52·6)* | ||
| Cocaine use disorders | 7·3 (6·6 to 8·1) | 42·2% (30·1 to 58·3)* | 0·1 (0·1 to 0·1) | 19·6% (9·2 to 33·0)* | 311·5 (281·5 to 344·1) | 35·6% (24·0 to 51·2)* | 3·9 (3·5 to 4·3) | 16·7% (6·5 to 30·0)* | ||
| Amphetamine use disorders | 4·5 (3·3 to 5·0) | 27·2% (0·8 to 41·0)* | 0·1 (0·0 to 0·1) | 8·7% (−14·0 to 20·7) | 206·9 (151·6 to 227·8) | 21·0% (−3·6 to 34·4) | 2·6 (1·9 to 2·8) | 5·6% (−15·5 to 17·4) | ||
| Other drug use disorders | 45·3 (42·9 to 48·2) | 35·2% (22·8 to 46·1)* | 0·6 (0·5 to 0·6) | 11·3% (1·2 to 19·9)* | 1687·6 (1589·4 to 1805·9) | 25·9% (14·0 to 37·3)* | 21·0 (19·8 to 22·5) | 8·2% (−2·0 to 17·8) | ||
| Diabetes and kidney diseases | 2611·2 (2557·8 to 2667·2) | 34·2% (32·0 to 36·2)* | 33·6 (32·9 to 34·3) | 1·3% (−0·3 to 2·7) | 58 116·9 (56 801·5 to 59 525·7) | 25·1% (23·0 to 27·2)* | 726·4 (710·0 to 744·4) | −1·1% (−2·8 to 0·6) | ||
| Diabetes mellitus | 1369·8 (1340·3 to 1401·9) | 34·7% (32·2 to 37·3)* | 17·5 (17·1 to 17·9) | 1·2% (−0·7 to 3·1) | 29 300·2 (28 711·5 to 29 950·1) | 29·9% (27·2 to 32·4)* | 363·1 (355·7 to 371·2) | 0·7% (−1·4 to 2·6) | ||
| Type 1 diabetes mellitus | 345·5 (319·3 to 371·1) | 15·1% (10·5 to 19·0)* | 4·3 (4·0 to 4·7) | −11·0% (−14·6 to −7·8)* | 9477·3 (8944·6 to 10 079·9) | 11·1% (7·2 to 14·3)* | 117·3 (110·8 to 124·6) | −10·6% (−13·9 to −7·9)* | ||
| Type 2 diabetes mellitus | 1024·3 (985·5 to 1066·8) | 43·0% (40·4 to 45·8)* | 13·2 (12·7 to 13·7) | 5·9% (4·1 to 8·0)* | 19 822·9 (19 013·8 to 20 687·8) | 41·3% (38·3 to 44·4)* | 245·8 (235·8 to 256·5) | 7·1% (5·0 to 9·4)* | ||
| Chronic kidney disease | 1230·2 (1195·1 to 1258·8) | 33·7% (30·5 to 36·1)* | 15·9 (15·5 to 16·3) | 1·5% (−0·9 to 3·2) | 28 508·5 (27 610·2 to 29 314·0) | 21·0% (18·2 to 23·5)* | 359·4 (348·2 to 369·6) | −2·5% (−4·7 to −0·6)* | ||
| Chronic kidney disease due to type 1 diabetes mellitus | 77·3 (62·4 to 95·2) | 23·2% (19·0 to 27·4)* | 0·9 (0·8 to 1·2) | −1·2% (−4·0 to 1·2) | 2622·0 (2121·7 to 3205·5) | 17·8% (13·6 to 22·3)* | 31·9 (25·9 to 38·9) | −2·9% (−5·6 to −0·3)* | ||
| Chronic kidney disease due to type 2 diabetes mellitus | 349·0 (306·8 to 395·9) | 40·5% (36·4 to 43·6)* | 4·5 (4·0 to 5·1) | 4·2% (1·4 to 6·2)* | 6671·9 (5825·5 to 7625·9) | 35·4% (31·0 to 38·7)* | 82·8 (72·4 to 94·5) | 2·9% (−0·2 to 5·2) | ||
| Chronic kidney disease due to hypertension | 347·4 (304·6 to 391·5) | 41·4% (37·4 to 44·2)* | 4·6 (4·0 to 5·2) | 3·2% (0·4 to 5·2)* | 5954·8 (5175·1 to 6741·9) | 33·4% (29·3 to 36·5)* | 75·2 (65·4 to 84·9) | 2·3% (−0·7 to 4·5) | ||
| Chronic kidney disease due to glomerulonephritis | 189·7 (165·2 to 217·3) | 25·5% (22·1 to 28·8)* | 2·4 (2·1 to 2·8) | −1·3% (−3·2 to 0·7) | 5554·9 (4929·1 to 6250·8) | 12·7% (9·6 to 16·1)* | 70·6 (62·8 to 79·4) | −5·5% (−7·5 to −3·3)* | ||
| Chronic kidney disease due to other and unspecified causes | 266·8 (232·8 to 304·0) | 25·9% (22·4 to 29·4)* | 3·4 (3·0 to 3·9) | −1·4% (−3·7 to 0·6) | 7704·8 (6794·9 to 8614·8) | 10·0% (6·8 to 13·4)* | 98·9 (87·4 to 110·0) | −7·7% (−9·9 to −5·4)* | ||
| Acute glomerulonephritis | 11·2 (10·5 to 12·1) | 14·7% (8·7 to 22·3)* | 0·1 (0·1 to 0·2) | −9·5% (−14·5 to −3·5)* | 308·2 (282·4 to 336·8) | −5·5% (−10·4 to 2·2) | 3·9 (3·6 to 4·3) | −20·9% (−25·1 to −15·1)* | ||
| Skin and subcutaneous diseases | 100·3 (65·3 to 131·7) | 42·3% (34·9 to 52·0)* | 1·3 (0·9 to 1·7) | 8·1% (2·7 to 16·5)* | 2517·9 (1703·3 to 3283·8) | 26·1% (18·6 to 35·7)* | 33·1 (22·4 to 43·2) | 5·0% (−1·2 to 13·8) | ||
| Bacterial skin diseases | 76·0 (48·7 to 95·6) | 45·5% (36·8 to 54·9)* | 1·0 (0·6 to 1·3) | 12·7% (6·0 to 20·7)* | 2096·6 (1378·0 to 2691·9) | 26·4% (18·0 to 36·9)* | 27·6 (18·2 to 35·6) | 6·4% (−0·6 to 15·9) | ||
| Cellulitis | 18·9 (10·3 to 26·0) | 57·0% (45·8 to 67·1)* | 0·2 (0·1 to 0·3) | 19·6% (9·8 to 28·2)* | 480·1 (264·6 to 640·2) | 38·3% (30·8 to 50·4)* | 6·2 (3·4 to 8·3) | 13·7% (7·3 to 23·9)* | ||
| Pyoderma | 57·1 (35·8 to 70·8) | 42·1% (32·4 to 52·4)* | 0·8 (0·5 to 0·9) | 10·5% (3·2 to 19·0)* | 1616·4 (1051·6 to 2136·7) | 23·3% (14·3 to 35·0)* | 21·5 (14·1 to 28·8) | 4·5% (−3·2 to 15·0) | ||
| Decubitus ulcer | 20·3 (13·2 to 30·6) | 32·4% (22·9 to 51·0)* | 0·3 (0·2 to 0·4) | −5·1% (−12·2 to 9·2) | 321·7 (211·2 to 471·5) | 26·2% (17·9 to 42·5)* | 4·2 (2·7 to 6·1) | −2·3% (−8·8 to 11·5) | ||
| Other skin and subcutaneous diseases | 3·9 (2·6 to 7·2) | 35·8% (26·6 to 49·6)* | 0·1 (0·0 to 0·1) | 3·3% (−3·5 to 14·4) | 99·6 (69·4 to 165·8) | 19·1% (10·8 to 34·1)* | 1·3 (0·9 to 2·2) | 0·7% (−6·1 to 13·1) | ||
| Musculoskeletal disorders | 121·3 (105·6 to 126·2) | 30·9% (25·1 to 35·1)* | 1·6 (1·4 to 1·6) | −0·1% (−4·4 to 3·2) | 2842·7 (2440·7 to 2953·1) | 19·6% (13·7 to 23·2)* | 35·9 (30·8 to 37·3) | −2·5% (−7·1 to 0·4) | ||
| Rheumatoid arthritis | 47·3 (39·0 to 51·2) | 25·8% (16·2 to 31·9)* | 0·6 (0·5 to 0·7) | −5·9% (−12·9 to −1·2)* | 866·0 (707·8 to 941·4) | 17·9% (8·6 to 23·3)* | 10·9 (8·9 to 11·8) | −9·1% (−16·1 to −5·0)* | ||
| Other musculoskeletal disorders | 74·0 (66·1 to 78·7) | 34·4% (30·2 to 38·8)* | 1·0 (0·9 to 1·0) | 3·9% (0·9 to 7·5)* | 1976·6 (1730·3 to 2089·1) | 20·3% (15·6 to 24·0)* | 25·0 (21·9 to 26·4) | 0·8% (−3·0 to 3·8) | ||
| Other non-communicable diseases | 1153·3 (1101·8 to 1208·3) | 0·8% (−3·9 to 4·0) | 16·3 (15·5 to 17·1) | −11·2% (−15·3 to −8·5)* | 68 240·8 (64 835·4 to 72 452·1) | −10·6% (−15·8 to −6·9)* | 993·0 (941·3 to 1054·3) | −16·4% (−21·3 to −12·8)* | ||
| Congenital anomalies | 584·9 (556·3 to 618·3) | −14·3% (−21·1 to −10·1)* | 8·7 (8·2 to 9·2) | −18·2% (−24·7 to −14·1)* | 48 860·4 (46 405·7 to 51 687·3) | −15·3% (−22·0 to −11·0)* | 729·4 (692·5 to 771·7) | −18·8% (−25·2 to −14·6)* | ||
| Neural tube defects | 61·7 (46·7 to 83·7) | −13·1% (−24·5 to −1·0)* | 0·9 (0·7 to 1·3) | −16·5% (−27·6 to −4·8)* | 5317·5 (4017·1 to 7217·5) | −13·4% (−24·8 to −1·4)* | 80·0 (60·4 to 108·6) | −16·7% (−27·7 to −5·0)* | ||
| Congenital heart anomalies | 261·2 (216·6 to 308·2) | −17·9% (−24·6 to −9·8)* | 3·9 (3·2 to 4·6) | −21·8% (−28·1 to −14·1)* | 21 634·4 (17 770·6 to 25 604·8) | −18·9% (−25·5 to −10·8)* | 321·7 (263·6 to 381·4) | −22·4% (−28·7 to −14·6)* | ||
| Orofacial clefts | 3·8 (1·5 to 8·8) | −40·0% (−54·5 to −22·5)* | 0·1 (0·0 to 0·1) | −41·9% (−55·9 to −25·1)* | 331·3 (130·1 to 770·5) | −40·0% (−54·5 to −22·7)* | 5·0 (2·0 to 11·7) | −41·9% (−56·0 to −25·2)* | ||
| Down syndrome | 26·1 (21·3 to 35·1) | 3·1% (−7·4 to 17·4) | 0·4 (0·3 to 0·5) | −5·2% (−14·2 to 7·0) | 1906·1 (1481·7 to 2707·9) | −1·4% (−11·5 to 13·9) | 27·7 (21·3 to 39·8) | −7·3% (−16·7 to 7·1) | ||
| Other chromosomal abnormalities | 17·9 (12·0 to 26·3) | 4·6% (−6·3 to 18·2) | 0·3 (0·2 to 0·4) | 0·3% (−10·1 to 13·2) | 1507·9 (1012·2 to 2233·3) | 3·9% (−6·9 to 17·4) | 22·6 (15·1 to 33·5) | 0·0% (−10·4 to 13·0) | ||
| Congenital musculoskeletal and limb anomalies | 11·0 (8·6 to 14·0) | −8·7% (−17·3 to 0·0) | 0·2 (0·1 to 0·2) | −12·8% (−20·9 to −4·5)* | 912·2 (708·9 to 1172·9) | −9·8% (−18·2 to −1·0)* | 13·6 (10·6 to 17·5) | −13·3% (−21·5 to −4·9)* | ||
| Urogenital congenital anomalies | 14·1 (10·3 to 16·9) | −2·5% (−11·8 to 9·2) | 0·2 (0·1 to 0·2) | −8·5% (−17·1 to 2·1) | 1105·8 (781·3 to 1347·8) | −5·5% (−14·6 to 6·3) | 16·4 (11·5 to 20·0) | −9·7% (−18·3 to 1·3) | ||
| Digestive congenital anomalies | 50·8 (37·7 to 71·8) | −16·2% (−27·1 to −6·4)* | 0·8 (0·6 to 1·1) | −19·3% (−29·8 to −9·8)* | 4398·7 (3253·9 to 6229·0) | −16·5% (−27·3 to −6·7)* | 66·3 (49·0 to 93·9) | −19·4% (−29·9 to −9·9)* | ||
| Other congenital anomalies | 138·3 (102·3 to 175·6) | −12·4% (−20·1 to −0·5)* | 2·1 (1·5 to 2·6) | −15·9% (−23·3 to −4·5)* | 11 746·6 (8613·3 to 14 951·0) | −13·0% (−20·7 to −1·1)* | 176·1 (128·8 to 224·2) | −16·3% (−23·7 to −4·8)* | ||
| Urinary diseases and male infertility | 271·2 (263·9 to 282·2) | 39·6% (34·9 to 43·4)* | 3·6 (3·5 to 3·7) | 5·7% (2·2 to 8·5)* | 6255·2 (6044·8 to 6542·1) | 20·8% (15·5 to 24·9)* | 81·1 (78·3 to 84·8) | −0·7% (−5·1 to 2·7) | ||
| Urinary tract infections | 206·4 (197·9 to 223·2) | 48·3% (42·9 to 53·5)* | 2·7 (2·6 to 3·0) | 10·9% (7·2 to 14·5)* | 4522·3 (4285·2 to 5016·3) | 31·4% (24·4 to 38·8)* | 58·4 (55·2 to 65·0) | 7·2% (1·7 to 13·0)* | ||
| Urolithiasis | 12·3 (10·5 to 15·7) | 30·4% (19·0 to 49·4)* | 0·2 (0·1 to 0·2) | −1·2% (−9·7 to 12·9) | 255·1 (216·0 to 323·5) | 19·6% (9·7 to 36·9)* | 3·2 (2·7 to 4·0) | −5·9% (−13·6 to 7·7) | ||
| Other urinary diseases | 52·5 (42·3 to 58·0) | 15·0% (8·0 to 25·5)* | 0·7 (0·6 to 0·8) | −9·9% (−15·3 to −2·2)* | 1477·8 (1172·2 to 1660·2) | −3·0% (−9·6 to 6·4) | 19·4 (15·4 to 21·9) | −18·2% (−23·3 to −10·6)* | ||
| Gynaecological diseases | 8·2 (7·4 to 8·7) | 19·1% (5·1 to 30·0)* | 0·1 (0·1 to 0·1) | −2·6% (−13·6 to 6·0) | 292·9 (272·6 to 318·7) | 9·2% (−2·8 to 20·6) | 3·7 (3·4 to 4·0) | −6·0% (−15·4 to 3·6) | ||
| Uterine fibroids | 2·4 (1·6 to 3·0) | 33·3% (6·7 to 54·6)* | 0·0 (0·0 to 0·0) | 8·1% (−14·9 to 24·7) | 74·2 (52·7 to 95·5) | 13·0% (−4·2 to 31·6) | 0·9 (0·6 to 1·2) | −4·8% (−20·0 to 10·5) | ||
| Polycystic ovarian syndrome | 0·0 (0·0 to 0·0) | 12·9% (−12·8 to 50·4) | 0·0 (0·0 to 0·0) | 1·0% (−22·5 to 34·8) | 0·7 (0·1 to 1·5) | 10·1% (−15·8 to 51·2) | 0·0 (0·0 to 0·0) | −0·1% (−24·3 to 37·2) | ||
| Endometriosis | 0·2 (0·1 to 0·2) | 11·8% (−12·4 to 45·5) | 0·0 (0·0 to 0·0) | −3·2% (−23·8 to 25·5) | 7·7 (3·2 to 12·0) | 10·4% (−12·9 to 41·7) | 0·1 (0·0 to 0·1) | −3·2% (−23·2 to 24·3) | ||
| Genital prolapse | 0·6 (0·3 to 0·9) | 0·6% (−15·4 to 16·1) | 0·0 (0·0 to 0·0) | −24·1% (−36·0 to −13·0)* | 14·5 (6·8 to 20·1) | −4·4% (−18·4 to 10·4) | 0·2 (0·1 to 0·2) | −24·0% (−35·2 to −11·9)* | ||
| Other gynaecological diseases | 5·0 (4·1 to 5·6) | 16·0% (4·1 to 27·9)* | 0·1 (0·1 to 0·1) | −3·6% (−12·2 to 5·9) | 195·8 (163·0 to 228·9) | 8·9% (−2·9 to 20·6) | 2·5 (2·1 to 2·9) | −4·8% (−14·2 to 5·1) | ||
| Haemoglobinopathies and haemolytic anaemias | 104·6 (82·0 to 132·2) | 5·8% (−1·4 to 13·4) | 1·4 (1·1 to 1·8) | −11·3% (−17·6 to −4·8)* | 4831·6 (3643·1 to 6268·9) | −1·8% (−13·1 to 9·4) | 66·6 (50·0 to 86·2) | −11·1% (−21·6 to −0·5)* | ||
| Thalassaemias | 7·2 (6·0 to 8·4) | −23·7% (−32·6 to −12·7)* | 0·1 (0·1 to 0·1) | −27·9% (−36·5 to −17·2)* | 564·7 (474·8 to 667·6) | −24·6% (−33·9 to −13·2)* | 8·2 (6·9 to 9·7) | −28·6% (−37·6 to −17·6)* | ||
| Sickle cell disorders | 38·4 (24·0 to 54·8) | 3·7% (−11·6 to 17·7) | 0·5 (0·3 to 0·8) | −3·1% (−17·6 to 10·3) | 2796·4 (1747·3 to 3913·6) | 2·1% (−13·7 to 17·3) | 39·7 (24·8 to 55·3) | −3·9% (−19·1 to 11·0) | ||
| G6PD deficiency | 16·7 (12·1 to 22·5) | 11·8% (4·7 to 19·6)* | 0·2 (0·2 to 0·3) | −7·1% (−12·1 to −1·0)* | 692·6 (522·0 to 896·1) | 4·4% (−2·5 to 12·3) | 8·8 (6·7 to 11·4) | −9·6% (−15·0 to −3·3)* | ||
| Other haemoglobinopathies and haemolytic anaemias | 42·2 (35·1 to 49·2) | 13·0% (9·3 to 16·5)* | 0·6 (0·5 to 0·6) | −16·1% (−18·7 to −13·4)* | 777·8 (634·5 to 917·2) | 1·3% (−2·2 to 4·8) | 9·9 (8·1 to 11·7) | −19·9% (−22·3 to −17·4)* | ||
| Endocrine, metabolic, blood, and immune disorders | 144·5 (115·1 to 152·3) | 28·2% (19·7 to 33·3)* | 1·9 (1·5 to 2·0) | 0·8% (−5·0 to 4·4) | 4506·4 (3762·3 to 4919·9) | 10·4% (2·7 to 16·9)* | 59·7 (50·0 to 65·5) | −5·5% (−11·2 to −0·2)* | ||
| Sudden infant death syndrome | 40·0 (18·0 to 77·0) | −17·3% (−28·6 to −1·4)* | 0·6 (0·3 to 1·2) | −20·2% (−31·2 to −4·9)* | 3494·3 (1570·1 to 6734·0) | −17·3% (−28·6 to −1·4)* | 52·7 (23·7 to 101·5) | −20·2% (−31·2 to −4·9)* | ||
| Injuries | 4484·7 (4332·0 to 4585·6) | 2·3% (0·5 to 4·0)* | 57·9 (55·9 to 59·2) | −13·7% (−15·1 to −12·2)* | 195 231·1 (188 807·7 to 199 825·5) | −6·4% (−7·8 to −4·8)* | 2548·3 (2461·9 to 2609·6) | −16·9% (−18·2 to −15·3)* | ||
| Transport injuries | 1335·0 (1289·1 to 1369·5) | −3·1% (−6·0 to −0·6)* | 17·0 (16·4 to 17·4) | −17·0% (−19·5 to −14·9)* | 61 937·8 (60 031·2 to 63 736·5) | −9·6% (−11·8 to −7·3)* | 800·5 (775·9 to 823·3) | −19·5% (−21·4 to −17·5)* | ||
| Road injuries | 1243·1 (1191·9 to 1276·9) | −3·2% (−6·3 to −0·5)* | 15·8 (15·2 to 16·3) | −17·1% (−19·7 to −14·9)* | 57 638·4 (55 500·8 to 59 369·2) | −9·7% (−12·0 to −7·3)* | 745·0 (718·1 to 767·4) | −19·6% (−21·6 to −17·5)* | ||
| Pedestrian road injuries | 486·2 (459·7 to 535·0) | −6·4% (−11·7 to −2·1)* | 6·2 (5·9 to 6·8) | −21·4% (−25·5 to −17·9)* | 20 850·8 (19 596·0 to 23 164·4) | −14·8% (−18·7 to −11·0)* | 270·4 (253·9 to 300·8) | −25·1% (−28·3 to −21·9)* | ||
| Cyclist road injuries | 68·9 (59·2 to 76·2) | 9·1% (1·8 to 16·4)* | 0·9 (0·7 to 1·0) | −8·8% (−14·8 to −2·5)* | 2853·5 (2471·6 to 3209·0) | 1·0% (−5·7 to 8·3) | 36·3 (31·5 to 41·0) | −11·8% (−17·8 to −5·3)* | ||
| Motorcyclist road injuries | 225·7 (196·1 to 238·6) | −0·6% (−8·9 to 5·2) | 2·9 (2·5 to 3·0) | −12·4% (−19·5 to −7·3)* | 11 416·3 (9969·6 to 12 098·0) | −5·7% (−12·5 to −0·5)* | 146·2 (127·5 to 154·9) | −14·8% (−20·7 to −10·1)* | ||
| Motor vehicle road injuries | 451·1 (423·4 to 472·9) | −2·5% (−6·2 to 1·3) | 5·8 (5·4 to 6·0) | −15·6% (−18·6 to −12·2)* | 22 004·1 (20 639·8 to 23 130·9) | −7·8% (−10·4 to −3·0)* | 285·3 (267·6 to 299·7) | −17·2% (−19·6 to −12·8)* | ||
| Other road injuries | 11·2 (9·9 to 12·8) | −5·5% (−11·0 to 16·1) | 0·1 (0·1 to 0·2) | −19·4% (−24·1 to −1·3)* | 513·8 (454·1 to 583·4) | −11·7% (−17·3 to 10·6) | 6·7 (5·9 to 7·6) | −21·4% (−26·5 to −1·7)* | ||
| Other transport injuries | 91·9 (84·5 to 107·2) | −1·5% (−6·2 to 3·7) | 1·2 (1·1 to 1·4) | −15·5% (−19·5 to −10·9)* | 4299·4 (3919·6 to 5048·3) | −7·8% (−12·6 to −2·4)* | 55·4 (50·5 to 65·0) | −17·9% (−22·2 to −13·2)* | ||
| Unintentional injuries | 1804·9 (1695·7 to 1872·0) | 2·9% (0·5 to 6·0)* | 23·8 (22·4 to 24·7) | −15·3% (−17·3 to −12·8)* | 69 430·5 (64 685·1 to 72 366·8) | −12·8% (−15·0 to −9·6)* | 928·8 (865·6 to 969·3) | −23·0% (−25·0 to −20·0)* | ||
| Falls | 695·8 (644·9 to 741·7) | 27·4% (21·2 to 35·6)* | 9·2 (8·5 to 9·8) | −2·8% (−7·4 to 3·4) | 16 688·1 (15 101·9 to 17 636·8) | 10·1% (4·8 to 17·2)* | 216·6 (196·4 to 228·6) | −8·4% (−12·7 to −2·5)* | ||
| Drowning | 295·2 (284·5 to 306·2) | −17·2% (−19·8 to −14·1)* | 4·0 (3·8 to 4·1) | −27·3% (−29·6 to −24·5)* | 16 563·3 (15 784·2 to 17 350·0) | −26·1% (−29·0 to −22·4)* | 228·3 (217·2 to 239·7) | −32·8% (−35·5 to −29·3)* | ||
| Fire heat and hot substances | 120·6 (101·6 to 129·4) | −7·9% (−10·9 to −1·2)* | 1·6 (1·3 to 1·7) | −22·9% (−25·4 to −17·3)* | 5286·3 (4308·9 to 5836·4) | −16·5% (−21·0 to −7·3)* | 71·0 (57·8 to 78·6) | −25·5% (−29·6 to −17·1)* | ||
| Poisonings | 72·4 (52·7 to 79·4) | −6·8% (−16·1 to 2·9) | 0·9 (0·7 to 1·0) | −20·8% (−28·4 to −12·5)* | 3321·7 (2454·1 to 3669·2) | −14·6% (−22·7 to −3·8)* | 44·1 (32·7 to 48·8) | −23·9% (−31·0 to −14·1)* | ||
| Poisoning by carbon monoxide | 35·5 (25·7 to 38·8) | −12·5% (−22·4 to −5·0)* | 0·5 (0·3 to 0·5) | −26·6% (−34·8 to −20·3)* | 1462·4 (1073·0 to 1613·6) | −19·1% (−27·2 to −11·8)* | 18·9 (13·8 to 20·9) | −29·0% (−36·2 to −22·4)* | ||
| Poisoning by other means | 36·9 (26·8 to 41·0) | −0·5% (−10·1 to 11·9) | 0·5 (0·4 to 0·5) | −14·4% (−22·4 to −3·9)* | 1859·3 (1385·8 to 2072·9) | −10·7% (−19·6 to 3·3) | 25·2 (19·0 to 28·1) | −19·6% (−27·7 to −6·8)* | ||
| Exposure to mechanical forces | 136·5 (117·6 to 143·2) | −6·7% (−9·8 to −3·7)* | 1·8 (1·5 to 1·8) | −20·3% (−22·9 to −17·8)* | 6385·5 (5500·4 to 6710·8) | −13·8% (−16·6 to −10·8)* | 84·0 (72·3 to 88·3) | −23·0% (−25·5 to −20·3)* | ||
| Unintentional firearm injuries | 22·6 (21·1 to 25·8) | −2·9% (−7·5 to 2·8) | 0·3 (0·3 to 0·3) | −16·4% (−20·3 to −11·5)* | 1094·5 (1013·5 to 1275·4) | −7·4% (−12·2 to −1·3)* | 14·4 (13·3 to 16·9) | −16·5% (−20·9 to −11·1)* | ||
| Other exposure to mechanical forces | 113·9 (94·7 to 120·8) | −7·4% (−10·6 to −4·1)* | 1·5 (1·2 to 1·6) | −21·0% (−23·7 to −18·3)* | 5291·0 (4401·1 to 5626·1) | −15·0% (−18·0 to −11·7)* | 69·6 (57·8 to 74·0) | −24·3% (−26·9 to −21·2)* | ||
| Adverse effects of medical treatment | 121·6 (103·6 to 137·6) | 16·6% (12·0 to 20·9)* | 1·6 (1·4 to 1·8) | −6·2% (−10·0 to −2·5)* | 4363·9 (3619·9 to 5234·0) | 4·0% (−1·2 to 11·0) | 58·1 (48·0 to 70·7) | −9·5% (−13·9 to −3·6)* | ||
| Animal contact | 81·1 (44·9 to 94·0) | −1·4% (−6·8 to 6·2) | 1·1 (0·6 to 1·2) | −16·0% (−20·5 to −9·6)* | 3911·9 (2167·6 to 4585·6) | −9·5% (−15·8 to 0·2) | 52·4 (29·0 to 61·8) | −19·2% (−25·2 to −10·2)* | ||
| Venomous animal contact | 70·9 (37·0 to 83·8) | −1·3% (−7·5 to 6·2) | 0·9 (0·5 to 1·1) | −16·0% (−21·0 to −9·7)* | 3407·7 (1758·4 to 4087·5) | −9·7% (−16·4 to −0·7)* | 45·5 (23·4 to 54·9) | −19·4% (−25·8 to −11·3)* | ||
| Non-venomous animal contact | 10·1 (7·1 to 14·4) | −1·6% (−15·3 to 10·2) | 0·1 (0·1 to 0·2) | −16·1% (−27·4 to −6·2)* | 504·2 (335·8 to 750·1) | −7·9% (−26·1 to 6·5) | 6·9 (4·5 to 10·3) | −17·2% (−33·6 to −4·3)* | ||
| Foreign body | 124·1 (119·3 to 130·0) | 1·7% (−1·9 to 4·8) | 1·7 (1·6 to 1·8) | −14·1% (−17·0 to −11·6)* | 5907·0 (5566·3 to 6301·2) | −12·4% (−16·4 to −8·3)* | 83·3 (78·3 to 88·9) | −20·1% (−23·8 to −16·3)* | ||
| Pulmonary aspiration and foreign body in airway | 115·7 (111·4 to 121·3) | 1·9% (−1·9 to 5·0) | 1·6 (1·5 to 1·7) | −13·9% (−17·0 to −11·4)* | 5526·1 (5212·6 to 5910·0) | −12·2% (−16·6 to −8·0)* | 78·1 (73·5 to 83·7) | −19·9% (−23·8 to −16·0)* | ||
| Foreign body in other body part | 8·4 (7·5 to 10·3) | −0·5% (−6·9 to 7·1) | 0·1 (0·1 to 0·1) | −15·8% (−20·8 to −10·0)* | 381·0 (326·2 to 474·4) | −14·4% (−21·1 to −6·2)* | 5·2 (4·4 to 6·5) | −23·3% (−29·2 to −16·1)* | ||
| Environmental heat and cold exposure | 53·3 (36·8 to 59·2) | −13·2% (−22·4 to −8·4)* | 0·7 (0·5 to 0·8) | −29·4% (−37·1 to −25·4)* | 1845·6 (1246·6 to 2066·2) | −21·4% (−28·8 to −17·5)* | 23·7 (15·8 to 26·7) | −32·7% (−39·5 to −29·1)* | ||
| Exposure to forces of nature | 9·6 (8·7 to 11·0) | −38·0% (−43·9 to −28·9)* | 0·1 (0·1 to 0·1) | −45·8% (−50·8 to −37·9)* | 477·6 (438·4 to 544·3) | −45·0% (−49·4 to −37·3)* | 6·3 (5·8 to 7·2) | −50·2% (−54·2 to −43·2)* | ||
| Other unintentional injuries | 94·7 (91·9 to 98·3) | −14·5% (−16·7 to −12·1)* | 1·2 (1·2 to 1·3) | −25·8% (−27·6 to −23·8)* | 4679·6 (4519·4 to 4888·2) | −20·7% (−22·9 to −18·1)* | 60·9 (58·8 to 63·7) | −28·9% (−30·9 to −26·6)* | ||
| Self-harm and interpersonal violence | 1344·8 (1283·1 to 1380·4) | 7·3% (4·6 to 9·7)* | 17·1 (16·3 to 17·5) | −7·6% (−9·9 to −5·5)* | 63 862·9 (61 029·9 to 65 755·7) | 5·4% (2·8 to 7·7)* | 819·0 (782·2 to 843·4) | −5·7% (−7·9 to −3·7)* | ||
| Self-harm | 793·8 (743·5 to 819·7) | 1·1% (−2·6 to 3·7) | 10·0 (9·4 to 10·3) | −14·8% (−18·0 to −12·6)* | 33 577·2 (31 449·3 to 34 719·1) | −3·4% (−7·0 to −0·9)* | 423·6 (396·9 to 438·2) | −15·1% (−18·4 to −12·9)* | ||
| Self-harm by firearm | 63·8 (54·6 to 78·6) | 6·8% (2·3 to 10·8)* | 0·8 (0·7 to 1·0) | −10·3% (−13·9 to −7·2)* | 2653·6 (2241·9 to 3288·1) | 0·9% (−3·5 to 5·5) | 33·5 (28·2 to 41·6) | −11·5% (−15·2 to −7·6)* | ||
| Self-harm by other specified means | 730·0 (678·5 to 754·9) | 0·6% (−3·2 to 3·4) | 9·2 (8·5 to 9·5) | −15·2% (−18·4 to −12·8)* | 30 923·6 (28 832·4 to 32 098·2) | −3·7% (−7·5 to −1·1)* | 390·1 (363·6 to 405·1) | −15·4% (−18·8 to −13·1)* | ||
| Interpersonal violence | 405·3 (365·2 to 431·7) | 0·5% (−2·0 to 3·2) | 5·2 (4·7 to 5·5) | −11·1% (−13·3 to −8·7)* | 21 439·8 (19 275·8 to 22 799·8) | −1·6% (−4·4 to 1·3) | 276·8 (248·4 to 294·2) | −10·9% (−13·4 to −8·2)* | ||
| Assault by firearm | 174·4 (147·9 to 188·9) | 7·5% (4·3 to 10·8)* | 2·2 (1·9 to 2·4) | −3·6% (−6·5 to −0·5)* | 9541·2 (8106·2 to 10 291·7) | 5·4% (2·1 to 9·0)* | 122·9 (104·3 to 132·4) | −3·7% (−6·7 to −0·4)* | ||
| Assault by sharp object | 91·4 (74·4 to 111·2) | −11·5% (−15·3 to −6·0)* | 1·2 (0·9 to 1·4) | −22·3% (−25·6 to −17·6)* | 4634·5 (3747·0 to 5648·9) | −13·9% (−17·6 to −8·5)* | 59·2 (47·8 to 72·1) | −22·6% (−25·9 to −17·8)* | ||
| Assault by other means | 139·5 (123·6 to 164·4) | 1·3% (−3·4 to 5·6) | 1·8 (1·6 to 2·1) | −11·5% (−15·4 to −7·6)* | 7264·1 (6400·8 to 8583·0) | −1·3% (−5·4 to 3·6) | 94·7 (83·3 to 111·5) | −11·2% (−14·9 to −6·8)* | ||
| Conflict and terrorism | 129·7 (118·1 to 143·2) | 118·0% (88·8 to 148·6)* | 1·7 (1·6 to 1·9) | 98·4% (72·4 to 126·1)* | 7966·6 (7244·5 to 8855·9) | 113·5% (84·5 to 146·8)* | 107·3 (97·6 to 119·1) | 97·9% (71·0 to 128·8)* | ||
| Executions and police conflict | 16·0 (15·7 to 16·3) | 203·9% (186·9 to 220·9)* | 0·2 (0·2 to 0·2) | 172·4% (156·8 to 187·6)* | 879·3 (862·3 to 898·1) | 202·1% (184·8 to 219·8)* | 11·4 (11·2 to 11·7) | 176·4% (160·5 to 192·9)* | ||
Data in parentheses are 95% uncertainty intervals. G6PD=glucose-6-phosphate dehydrogenase. GBD=Global Burden of Diseases, Injuries, and Risk Factors Study. H influenzae=Haemophilus influenzae. NASH=non-alcoholic steatohepatitis. YLL=years of life lost.
*
Percentage changes that are statistically significant.