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. 2018 Jun 8;89(11):1208–1214. doi: 10.1136/jnnp-2018-317970

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Correlations between AS and neuroimaging measures. (A): mean ¹¹C-PBB3 SUVR values in OFC showed significant and positive correlation with AS scores (r=0.53, p=0.037). (B and C): mean OFC thickness (r=−0.53, p=0.033) and mean FA value of UNC (r=−0.51, p=0.044) showed significant and negative correlation with AS scores. Mean ¹¹C-PiB SUVR values in OFC were not correlated with AS scores (p=0.408; data not shown). Filled and open circles indicate AD patients with high and low AS scores, respectively. ¹¹C-PBB3, ¹¹C-pyridinyl-butadienyl-benzothiazole 3; ¹¹C-PiB, ¹¹C-Pittsburgh compound-B; AS, Apathy Scale; FA, fractional anisotropy; OFC, orbitofrontal cortex; SUVR, standardised uptake value ratio; UNC, uncinate fasciculus.