Table 2.
Group comparison of estimated PET and MRI data between AD patients with high and low AS scores
| Patients with AD | t | P values | HC | ||
| High AS scores | Low AS scores | ||||
| 11C-PBB3 SUVR | |||||
| Frontal cortex | 1.10 (0.11) | 0.94 (0.09) | 3.16 | 0.006* | 0.86 (0.04)† |
| Lateral temporal cortex | 1.17 (0.12) | 1.05 (0.06) | 2.77 | 0.015 | 0.95 (0.04)†‡ |
| Medial temporal cortex | 1.09 (0.10) | 1.02 (0.05) | 1.56 | 0.140 | 0.99 (0.05)† |
| Parietal cortex | 1.08 (0.10) | 0.97 (0.09) | 2.16 | 0.048 | 0.83 (0.05)†‡ |
| Occipital cortex | 1.14 (0.11) | 1.05 (0.07) | 1.96 | 0.069 | 0.90 (0.03)†‡ |
| Orbitofrontal cortex | 1.14 (0.98) | 0.98 (0.07) | 3.12 | 0.007* | 0.92 (0.05)† |
| Anterior cingulate cortex | 1.12 (0.17) | 0.94 (0.10) | 2.45 | 0.027 | 0.91 (0.07)† |
| 11C-PiB SUVR | |||||
| Frontal cortex | 1.96 (0.43) | 1.79 (0.47) | 0.80 | 0.438 | 1.00 (0.05)†‡ |
| Lateral temporal cortex | 1.96 (0.46) | 1.86 (0.42) | 0.46 | 0.656 | 1.02 (0.04)†‡ |
| Medial temporal cortex | 1.56 (0.26) | 1.50 (0.23) | 0.52 | 0.611 | 1.07 (0.04)†‡ |
| Parietal cortex | 1.93 (0.40) | 1.85 (0.49) | 0.34 | 0.736 | 0.95 (0.05)†‡ |
| Occipital cortex | 1.74 (0.31) | 1.65 (0.27) | 0.62 | 0.542 | 0.97 (0.05)†‡ |
| Orbitofrontal cortex | 2.01 (0.45) | 1.81 (0.46) | 0.87 | 0.397 | 1.01 (0.11)†‡ |
| Anterior cingulate cortex | 2.31 (0.57) | 2.05 (0.56) | 0.91 | 0.377 | 1.17 (0.07)†‡ |
Values are listed as mean (SD).
*Low AS scores<high AS scores.
†HC<high AS scores.
‡HC<low AS scores (p<0.071).
11C-PBB3, 11C-pyridinyl-butadienyl-benzothiazole 3; 11C-PiB, 11C-Pittsburgh compound-B; AD, Alzheimer’s disease; AS, Apathy Scale; HC, cognitive healthy control; PET, positron emission tomography; SUVR, standard uptake value ratio.