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. 2018 Nov 6;13:7135–7153. doi: 10.2147/IJN.S182445

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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In vitro cytotoxicity studies of (A) different nanocomplexes, (B) DHP₁₆ at different W/W ratios, (C) PAMAM, PSSP, and PSSP-RGD₁₆ conjugates at different concentrations in A549 cells. Evaluation of the cellular uptake of different nanocomplexes in (D) A549 cells, and (E) MCF-7 cells by flow cytometry.

Note: *P,0.05 vs control group (n=3).

Abbreviations: DHP, pDNA/HMGB1/PAMAM-SS-PEG-RGD; DHPAMAM, pDNA/HMGB1/PAMAM; DHPP, pDNA/HMGB1/PAMAM-PEG; DHPSSP, pDNA/HMGB1/PSSP; DP, pDNA/PSSP-RGD; FITC, fluorescein; PAMAM, polyamidoamine; PEG, polyethylene glycol; PSSP, PAMAM-SS-PEG; RGD, arginine-glycine-aspartate.