Table 2.
Association of Baseline Biomarker Concentration With 18 Month Change in Global Cognition in All 93 Patients Evaluated
| Biomarker | Biomarker (baseline cognition) | Biomarker × Time (annual rate of change of cognition) | ||
|---|---|---|---|---|
| Parameter estimate† (SE) | p-Value | Parameter estimate† (SE) | p-Value | |
| TRAIL | 0.082 (0.152) | .589 | 0.114 (0.030) | <.001 |
| OPG/TRAIL | −0.146 (0.126) | .247 | −0.074 (0.024) | .003 |
| Dkk1 | −0.248 (0.280) | .376 | −0.168 (0.068) | .014 |
| CTX-1 | 0.074 (0.188) | .693 | −0.078 (0.038) | .046 |
| PINP | −0.208 (0.202) | .307 | −0.070 (0.042) | .096 |
| PTH | −0.002 (0.016) | .855 | 0.040 (0.028) | .159 |
| Total osteocalcin | −0.202 (0.264) | .443 | −0.068 (0.052) | .194 |
| Osteopontin | 0.072 (0.134) | .596 | −0.028 (0.030) | .350 |
| Sclerostin | −0.316 (0.238) | .190 | 0.022 (0.050) | .658 |
| Aβ40 | −0.076 (0.134) | .576 | −0.012 (0.030) | .712 |
| Undercarboxylated osteocalcin | 0.124 (0.114) | .283 | 0.008 (0.024) | .742 |
| OPG/RANKL | −0.052 (0.072) | .472 | 0.004 (0.016) | .827 |
| RANKL | 0.028 (0.076) | .712 | −0.002 (0.016) | .855 |
| Carboxlyated osteocalcin | −0.224 (0.128) | .082 | −0.002 (0.026) | .912 |
| OPG | −0.256 (0.212) | .232 | −0.004 (0.044) | .926 |
| Aβ42 | −0.196 (0.184) | .286 | −0.000 (0.040) | .980 |
Note: †The effect of a log unit change in biomarker concentration on annual rate of change in cognition from mixed-effects model adjusted for age, sex, and education. Significant associations are bolded for clarity.