Table 2.
Parameters of base case and sensitivity analyses. There were no CKD 1 patients as the initial eGFR was below 90 mL/min/1.73 m^2. Hence, we did not perform sensitivity analyses of mortality rate, utility, and cost for CKD 1 patients
| Parameters | Baseline values | Sensitivity analyses | Ref. | |
|---|---|---|---|---|
| Lower limit | Upper limit | |||
| Mean of eGFR decline speed (mL/min/1.73 m^2/year) | 2.2 | 0.1 | 10 | [33] |
| Standard Deviation of eGFR delcline speed (mL/min/1.73 m^2/year) | 6.5 | 0.1 | 10 | [33] |
| Initial age (years) | 37 | 30 | 60 | [33] |
| Initial eGFR (mL/min/1.73 m^2) | 73 | 30 | 75 | [33] |
| Baseline mortality rate of predialysis patients | 3.338 × 10−5 × e0.091 × age(male) 1.615 × 10−5 × e0.098 × age(female) |
× 0.8 | × 1.2 | [34, 35] |
| Mortality rate of CKD 1 patients | Baseline × 1 | × 0.9 | × 1.1 | [36] |
| Mortality rate of CKD 2 patients | Baseline × 1 | × 0.9 | × 1.1 | [36] |
| Mortality rate of CKD 3a patients | Baseline × 1.2 | × 1.1 | × 1.3 | [36] |
| Mortality rate of CKD 3b patients | Baseline × 1.8 | × 1.7 | × 1.9 | [36] |
| Mortality rate of CKD 4 patients | Baseline × 3.2 | × 3.0 | × 3.4 | [36] |
| Mortality rate of CKD 5 patients | Baseline × 5.9 | × 5.6 | × 6.2 | [36] |
| Mortality rate of dialysis patients | 1.32 × 10−3 × e0.060 × age | × 0.8 | × 1.2 | [36] |
| Utility of CKD 1 patients | 1 | 0.9 | 1 | [12] |
| Utility of CKD 2 patients | 0.9 | 0.8 | 1 | [12] |
| Utility of CKD 3a patients | 0.87 | 0.77 | 0.97 | [12] |
| Utility of CKD 3b patients | 0.85 | 0.75 | 0.95 | [12] |
| Utility of CKD 4 patients | 0.85 | 0.75 | 0.95 | [12] |
| Utility of CKD 5 patients | 0.85 | 0.75 | 0.95 | [12] |
| Utility of dialysis patients | 0.72 | 0.62 | 0.82 | [12] |
| Cost of CKD 1 (1000 USD / year) | 1.6 | 0.8 | 3.2 | [46] |
| Cost of CKD 2 (1000 USD / year) | 1.7 | 0.9 | 3.4 | [46] |
| Cost of CKD 3a (1000 USD / year) | 3.5 | 1.8 | 7.0 | [46] |
| Cost of CKD 3b (1000 USD / year) | 3.5 | 1.8 | 7.0 | [46] |
| Cost of CKD 4 (1000 USD / year) | 12.7 | 6.4 | 25.4 | [46] |
| Cost of CKD 5 (1000 USD / year) | 12.7 | 6.4 | 25.4 | [46] |
| Cost of dialysis patients (1000 USD / year) | 84.6 | 42.3 | 169.1 | [2] |
| Improve rate of eGFR decline slope | 0.59 | 0.1 | 0.9 | [33] |
| Annual discount rate for costs | 0.03 | 0 | 0.1 | |
| Annual discount rate for utilities | 0.03 | 0 | 0.1 | |
CKD Chronic kidney disease, eGFR Estimated glomerular filtration rate, Ref Reference