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. 2018 Nov 9;10:141. doi: 10.1186/s13148-018-0571-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Terms of Gene Ontology biological processes enriched in the comparison between SAC and hmMSI-H for their methyloma profile. The scatterplot shows the biological processes which are globally differentially methylated between SAC and hmMSI-H after GO term redundancy reduction. The graph is represented in a two-dimensional space derived by applying multidimensional scaling to a matrix of the GO terms’ semantic similarities [35]. Terms associated with higher methylation in hmMSI-H are shown in red squares. Colour intensity indicates level of significance (log10 p value). Circle diameter indicates number of genes for each biological process