Table 2.
Unadjusted and Adjusted Associations of sxKOA and HAQ Scores with Incident CVD
| Variable | Unadjusted | Model 1a | Model 2a |
|---|---|---|---|
| OR (95% CI) | OR (95% CI) | OR (95% CI) | |
| sxKOA vs. no sxKOA at baseline | 1.50 (1.08, 2.08) | 1.14 (0.80, 1.61) | 1.10 (0.76, 1.61) |
| Baseline 0 < HAQ < 1 vs. HAQ = 0 | 1.29 (0.97, 1.72) | 1.17 (0.87, 1.57) | 1.08 (0.79, 1.47) |
| Baseline 1 ≤ HAQ vs. HAQ = 0 | 1.94 (1.32, 2.85) | 1.91 (1.27, 2.86) | 1.82 (1.18, 2.79) |
| Worsened HAQ vs. unchanged or improved | 2.51 (1.93, 3.27) | 2.49 (1.90, 3.25) | 2.35 (1.79, 3.10) |
| Age: 1 year increase | 1.02 (1.00, 1.03) | ||
| Gender: Female vs. Male | 1.28 (0.91, 1.80) | ||
| Race: Black vs. White | 1.13 (0.83, 1.54) | ||
| Education: <HS vs. HS or greater | 0.89 (0.65, 1.24) | ||
| Cohort: Enrichment vs. Original | 0.96 (0.69, 1.33) | ||
| BMI: 1 kg/m2 increase | 0.98 (0.95, 1.00) | ||
| WHR: 0.1 unit increase | 1.15 (0.98, 1.36) | ||
| Diabetes vs. not | 1.84 (1.21, 2.80) | ||
| Hypertension vs. not | 1.10 (0.81, 1.48) | ||
| High cholesterol vs. not | 1.03 (0.74, 1.44) | ||
| NSAIDs vs. not | 1.27 (0.94, 1.71) |
CI confidence interval, sxKOA symptomatic knee osteoarthritis, HAQ health assessment questionnaire, HS high school, BMI body mass index, WHR waist-to-hip ratio, NSAIDs non-steroidal anti-inflammatory drugs
aModels 1 and 2 are adjusted for all variables with data listed in the column