Table 1.

In vitro cytotoxicity of different extracts and fractions of B. rupestris and B. discolor against HepG2, MDA-MB-231 and A549 cell lines

Cell line	BRT	BRH	BRD	BRE	BRR	BDT	BDH	BDD	BDE	doxorubicin
HepG2	1.28	−2.078	−8.02	−8.43	−13.74	1.66	−7.43	−16.18	−6.62	91.28 ± 0.3
MDA-MB-231	−15.86	− 9.70	−18.83	−25.52	− 23.30	− 6.19	− 6.73	13.17	−20.64	97.69 ± 0.4
A549	0.44	−0.81	7.85	−8.37	−0.89	12.59	8.18	14.99	−6.52	98.05 ± 0.0

Results are presented as growth inhibition percentage at concentration of 20 μg/mL, mean (n = 1). Doxorubicin (2 μg/mL) was used as the reference drug, mean ± SD (n = 2). BRT: B. rupestris total methanol extract; BHT: B. rupestris n-hexane fraction; BRD: B. rupestris dichloromethane fraction; BRE: B. rupestris ethyl acetate fraction; BRR: B. rupestris remaining MeOH(aq) fraction; BDT: B. discolor total methanol extract; BDH: B. discolor n-hexane fraction; BDD: B. discolor dichloromethane fraction; BDE: B. discolor ethyl acetate fraction