Table 1.

Genes significantly altered by in vitro lithium treatment exclusively in lithium responders in the microarray dataset

Gene	FC	95% CI	p	q
FLJ36840	0.80	0.75–0.86	2.80E-06	0.006
FAM46C	1.24	1.16–1.33	3.10E-06	0.006
KLF6	1.28	1.19–1.39	3.80E-06	0.006
B4GALT6	0.82	0.76–0.88	1.30E-05	0.015
NUDT9P1	0.76	0.69–0.85	3.20E-05	0.028
SNORD12C	1.22	1.13–1.32	4.60E-05	0.036
MIRLET7E	1.23	1.13–1.34	0.0001	0.054
MYO15B	1.21	1.12–1.31	0.0001	0.055
SRSF6	1.18	1.10–1.27	0.0001	0.085
LINC01152	0.80	0.72–0.88	0.0002	0.113
ZNF493	0.84	0.77–0.91	0.0002	0.113
ZNF429	0.81	0.74–0.89	0.0003	0.114
CETN3	0.78	0.70–0.88	0.0003	0.114
NEDD1	0.86	0.81–0.92	0.0003	0.114
PSG6	0.86	0.80–0.92	0.0003	0.114
ZNF667-AS1	1.25	1.13–1.40	0.0003	0.114
PRRX1	0.84	0.77–0.91	0.0003	0.114
ZBED8	0.78	0.69–0.87	0.0003	0.117
ATF4	1.18	1.09–1.29	0.0004	0.137
ZNF724P	0.83	0.76–0.91	0.0005	0.156
TRIB1	1.16	1.08–1.26	0.0005	0.165
IMPAD1	0.82	0.74–0.90	0.0005	0.165
CR1L	0.84	0.77–0.92	0.0006	0.17
LOC100131860	0.81	0.73–0.90	0.0006	0.17
LDHC	1.17	1.08–1.26	0.0006	0.17
SNORA19	1.20	1.09–1.32	0.0006	0.171
MIR30E	0.81	0.72–0.90	0.0007	0.172
FBXO9	0.82	0.73–0.91	0.0008	0.189
SNORD59B	1.33	1.15.1–54	0.0008	0.189

CI, confidence interval; FC, fold change. Linear FCs were calculated as FC = 2^logFC using the estimates of the log2-fold-change corresponding to the effect of lithium treatment provided by limma. The significance threshold was set at q < 0.2 at this step.

Genes reported in bold were also found to be associated with lithium response in the genotyped dataset.