Table 2.
Summary of head twitch response (HTR) data for N,N-diallyltryptamine (DALT) and ring-substituted derivatives.
| Drug | One-Way ANOVA | Duration (min) | N | Dose (mg/kg) | HTR Counts (mean ± SEM) | ED50 (95% CI) (mg/kg) | ED50 (95% CI) (μmol/kg) |
|---|---|---|---|---|---|---|---|
| DALT | F(5,24) = 5.71, p < 0.002 | 30 | 5 | 0 | 3.6 ± 0.9 | 3.42 (2.44–4.79) | 12.3 (8.8–17.3) |
| 5 | 0.875 | 8.2 ± 2.8 | |||||
| 5 | 1.75 | 6.8 ± 2.6 | |||||
| 5 | 3.5 | 14.2 ± 4.3 | |||||
| 5 | 7 | 21.8 ± 4.4 ** | |||||
| 5 | 14 | 20.6 ± 2.7 ** | |||||
| 5-MeO-DALT | F(5,24) = 6.63, p=0.0005 | 20 | 5 | 0 | 3.0 ± 1.5 | 2.25 (1.82–2.78) | 7.3 (5.9–9.1) |
| 5 | 1.75 | 6.6 ± 1.0 | |||||
| 5 | 3.5 | 19.8 ± 1.5 ** | |||||
| 5 | 7 | 8.8 ± 2.6 | |||||
| 5 | 14 | 8.0 ± 4.9 | |||||
| 5-F-DALT | F(5,24) = 5.12, p < 0.003 | 30 | 5 | 0 | 4.4 ± 0.6 | 1.58 (1.09–2.28) | 5.4 (3.7–7.7) |
| 5 | 0.875 | 9.8 ± 2.6 | |||||
| 5 | 1.75 | 21.0 ± 5.7 | |||||
| 5 | 3.5 | 36.0 ± 6.8 ** | |||||
| 5 | 7 | 26.8 ± 7.1 * | |||||
| 5 | 14 | 21.0 ± 4.0 | |||||
| 5-Br-DALT | F(5,24) = 5.21, p < 0.003 | 30 | 5 | 0 | 3.4 ± 0.5 | 4.80 (2.70–8.54) | 13.5 (7.6–24.0) |
| 5 | 3.5 | 5.0 ± 0.3 | |||||
| 5 | 7 | 10.8 ± 2.7 * | |||||
| 5 | 14 | 8.6 ± 2.7 | |||||
| 5 | 28 | 1.4 ± 0.4 | |||||
| 5 | 56 | 1.4 ± 1.4 | |||||
| 4-HO-DALT | F(5,24) = 12.07, p <0.0001 | 5 | 5 | 0 | 1.2 ± 0.4 | 2.60 (2.01–3.35) | 8.3 (6.4–10.6) |
| 5 | 0.875 | 4.0 ± 3.3 | |||||
| 5 | 1.75 | 9.2 ± 3.7 | |||||
| 5 | 3.5 | 28.6 ± 4.1 ** | |||||
| 5 | 7 | 31.6 ± 4.9 ** | |||||
| 5 | 14 | 24.6 ± 4.7 ** | |||||
| 4-AcO-DALT | F(5,24) = 6.87, p=0.0004 | 30 | 5 | 0 | 4.8 ± 1.0 | 1.99 (1.35–2.95) | 4.8 (3.3–7.1) |
| 5 | 0.875 | 10.4 ± 1.4 | |||||
| 5 | 1.75 | 42.0 ± 9.5 * | |||||
| 5 | 3.5 | 39.0 ± 14.1 * | |||||
| 5 | 7 | 65.0 ± 8.4 ** | |||||
| 5 | 14 | 47.8 ± 10.0 ** | |||||
| 2-Ph-DALT | F(5,24) = 2.20, NS | 30 | 5 | 0 | 3.8 ± 0.8 | ND | ND |
| 5 | 0.875 | 2.8 ± 0.5 | |||||
| 5 | 1.75 | 3.6 ± 1.3 | |||||
| 5 | 3.5 | 1.4 ± 0.5 | |||||
| 5 | 7 | 2.0 ± 0.5 | |||||
| 5 | 14 | 1.2 ± 0.5 | |||||
| 2-Me-5-MeO-DALT | F(5,24) = 1.02, NS | 30 | 5 | 0 | 3.8 ± 1.3 | ND | ND |
| 5 | 0.875 | 4.4 ± 0.2 | |||||
| 5 | 1.75 | 7.4 ± 2.2 | |||||
| 5 | 3.5 | 4.2 ± 1.0 | |||||
| 5 | 7 | 4.2 ± 0.9 | |||||
| 5 | 14 | 5.0 ± 1.4 | |||||
| 2-Me-5-F-DALT | F(5,24) = 0.19, NS | 30 | 5 | 0 | 5.4 ± 1.7 | ND | ND |
| 5 | 0.875 | 6.2 ± 1.0 | |||||
| 5 | 1.75 | 6.8 ± 0.9 | |||||
| 5 | 3.5 | 5.8 ± 2.5 | |||||
| 5 | 7 | 6.4 ± 1.6 | |||||
| 5 | 14 | 7.2 ± 0.8 | |||||
| 7-Et-DALT | F(1,10) = 0.11, NS | 30 | 6 | 0 | 10.7 ± 1.7 | ND | ND |
| 6 | 15 | 9.8 ± 1.8 | |||||
1
ND = not determined (the compound was not active within the dose range tested).
*
p < 0.05,
**
p < 0.01,
significant difference from the vehicle control group (Tukey’s test).