Table 3.

6-sulfatoxymelatonin (aMT6s) cosinor indices (mean ± SD), by group and in relation to treatment.

Cosinor indices	Baseline			After light administration
	Healthy volunteers	PBC	Cirrhosis	Healthy volunteers	PBC	Cirrhosis
	(n = 5)	(n = 7)	(n = 5)	(n = 5)	(n = 7)	(n = 5)
Mesor (pg/ml)	12.9 ± 7.3	8.7 ± 4.5	7.0 ± 5.4	12.6 ± 5.8	8.4 ± 5.7	9.3 ± 8.9
Amplitude (pg/ml)	17.0 ± 11.2	11.4 ± 7.0	7.5 ± 8.7	14.9 ± 10.0	10.1 ± 7.9	11.0 ± 12.6
Acrophase (clock time, hh:mm)	03:33 ± 01:24	04:00 ± 01:82	07:37 ± 07:45	03:49 ± 00:45	03:48 ± 01:09	08:00 ± 07:01
Rhythm (%)	84 ± 7	72 ± 17	68 ± 13	87 ± 6	81 ± 12	81 ± 16

These data refer only to individuals whose aMT6s cosinor fit was significant (p < 0.05 and % rhythm ≥50) both at baseline and after treatment.