Table 4.

Delta values of MAP, HR, and dP/dt_max during administration of phenylephrine or epinephrine for shock animals at each time point

	T1	T2	T3	T4
Responses to phenylephrine administration
ΔMAP, mmHg	33.5 (27.7, 41.7)	10.6 (6.1, 13)#	27.5 (16, 31.5)	27 (19.4, 29.5)
ΔHR, beats/min	−13.4 (−27, −9.1)	0.08 (−5.4, 1.9)#	−5.1 (−10.5, −0.6)	−10.1 (−12.5, −8.2)
Responses to epinephrine administration
ΔdP/dtmax, mmHg/s	3,401.2 (2,678.2, 3,552.7)	1,602.7 (946.1, 1,986.5)#	2,188.6 (1,983.2, 3,082.3)	2,349.2 (1,826.8, 2,515.6)

Delta values (i.e., difference between final value and starting value) are medians (25th, 75th percentiles). MAP, mean arterial pressure; HR, heart rate; dP/dt_max, maximum 1st derivative of left ventricular pressure over time; T1, baseline; T2, after development of shock; T3, after fluid and vasopressor resuscitation; T4, after blood reinfusion. Comparisons between time points:

^#P < 0.05 vs. T1.