Table 1.
Comparisons of response rates (RR) progression free survival (PFS) in elotuzumab clinical trials.
| Phase | Regimen* | N* | Overall RR | Median PFS | References |
|---|---|---|---|---|---|
| I | Elo | 35 | 0% | N/A | (40) |
| I | Elo/Bor | 27 | 48% | 9.46 months | (41) |
| II | Elo/Bor/Dex vs. Bor/Dex | 150 | 66 vs. 63% | 9.7 vs. 6.9 months | (47) |
| I | Elo/Len/Dex | 28 | 82% | N/A | (48) |
| Ib/II | Elo/Len/Dex | 73 | 84% | 28.6 months | (49) |
| III | Elo/Len/Dex vs. Len/Dex | 646 | 79 vs. 66% | 19.4 vs. 14.9 months | (50) |
| II | Elo/Td/Dex | 40 | 38% | 3.9 months | (51) |
| II | Elo/Pom/Dex vs. Pom/Dex | 117 | 53 vs. 26% | 10.3 vs. 4.7 months | (52) |
Elo, elotuzumab; Bor, bortezomib; Dex, dexamethasone; Len, lenalidomide; Td, thalidomide; Pom, pomalidomide; n, number of evaluable patients.