Table 2.

Main biological functions of SLAMF7.

Function	References
SLAMF7 is a self-ligand	(56–58)
SLAMF7-S isoform lacking ITSM-like sequence	(59)
NK cells activation upon SLAMF7 engagement with mAbs	(57–62)
SLAMF7 preferentially recruits EAT-2 over SAP	(57, 61–65)
EAT-2 stimulates calcium mobilization and ERK activation	(63, 66)
SLAMF7 mediates inhibitory function in the absence of EAT-2	(37, 61, 67)
Memory-like NK cells lack EAT-2	(68, 69)
SLAMF7 signals through association with Mac-1 in macrophages	(36)