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. 2018 Nov 5;9:2540. doi: 10.3389/fimmu.2018.02540

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Copyright © 2018 Minskaia, Saraiva, Soares, Azevedo, Ribeiro, Kumar, Vieira and Lacerda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Methylation pattern of FOXP3 preTSDR region. CpG positions 1, 5, 8, and 9 within FOXP3 preTSDR show a certain degree of hypomethylation in CD34⁺ cells and Treg subtypes as compared to Tcon cells. (A) Schematic presentation of the FOXP3 preTSDR encoded in the reverse strand of Xp11.23. (B). Methylation pattern of the FOXP3 preTSDR in five cell populations: CD34⁺ (1), CD45RA⁺CD15s⁻ (2), CD45RA⁻CD15s⁻ (3), CD45RA⁻CD15s⁺ (4), and Tcon (5) of donors M6 and F3. CpGs 1-10 are numbered relative to the 5′-3′ direction of the coding (reverse) strand. Each horizontal line represents DNA from one cell with unmodified C in light blue and ^mC in dark blue. Methylation percentage for each CpG site was calculated based on the number of ^mCs in a total of 20 and summarized in panels below. (C) Methylation patterns of the FOXP3 preTSDR of individual donors with the average methylation pattern for all donors presented in the panel below. See also Supplementary Figures 1, 4.