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Simplified schematic representation involving supposed mechanisms of action of Lithium (Li+). This drug maintains the K+ channel open and increases neuron hyperpolarization which becomes less responsive to excitatory postsynaptic potential resulting in hypoexcitability of the neuron. PIP2, phosphoinositide biphosphate; IPPase, inositol polyphosphate and phosphatase; IMPase, inositol monophosphate phosphatase; GSK3, glycogen synthase kinase 3 beta
