Organ weights in mice deficient in either Niemann-Pick C1 (NPC1), sterol O-acyltransferase 2 (SOAT2), or both NPC1 and SOAT2. These mice were the same as those described in Fig. 1. Their body weights (g) at study were as follows: Npc1+/+:Soat2+/+ 22.3 ± 1.2, Npc1+/+:Soat2−/− 21.1 ± 1.2, Npc1−/−:Soat2+/+ 20.4 ± 1.5, Npc1−/−:Soat2−/− 19.2 ± 1.3. Organ weights are shown for liver (A), small intestine (B), spleen (C), lung (combined) (D) and brain (E). Values are means ± SE of data from 6 animals in each group. a,b,abStatistically significant differences as determined by 1-way ANOVA.