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. 2018 Jun 21;315(4):G473–G483. doi: 10.1152/ajpgi.00155.2018

Fig. 8.

Fig. 8.

Continuous activation of glial hM3Dq receptors in vivo decreases oral contraction amplitude of colonic migrating motor complexes (CMMCs). Effects of 0.13 mg/ml CNO in drinking water on CMMC characteristics including oral contraction amplitude (A) and integral (B); and aboral contraction amplitude (C) and integral (D). All data are expressed as percentage change from baseline after acclimation period. (n = 4–6 mice; Student’s t-test; *P < 0.05). CNO, clozapine-N-oxide; GFAP, glial fibrillary acidic protein; hM3Dq, modified human M3R; M3R, muscarinic type 3 receptor; WT, wild-type.